KLF2 mutation is the most frequent somatic change in splenic marginal zone lymphoma and identifies a subset with distinct genotype.

Clipson, A; Wang, M; de Leval, L; Ashton-Key, M; Wotherspoon, A; Vassiliou, G; Bolli, N; Grove, C; Moody, S; Escudero-Ibarz, L; Gundem, G; Brugger, K; Xue, X; Mi, E; Bench, A; Scott, M; Liu, H; Follows, G; Robles, E F; Martinez-Climent, J A; Oscier, D; Watkins, A J; Du, M-Q

Clipson, A; Wang, M; de Leval, L; Ashton-Key, M; Wotherspoon, A; Vassiliou, G; Bolli, N; Grove, C; Moody, S; Escudero-Ibarz, L; Gundem, G; Brugger, K; Xue, X; Mi, E; Bench, A; Scott, M; Liu, H; Follows, G; Robles, E F; Martinez-Climent, J A; Oscier, D; Watkins, A J; Du, M-Q.

Afiliação

Clipson A; Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, UK.
Wang M; Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, UK.
de Leval L; Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Ashton-Key M; Department of Cellular Pathology, Southampton University Hospitals National Health Service Trust, Southampton, UK.
Wotherspoon A; Department of Histopathology, Royal Marsden Hospital, London, UK.
Vassiliou G; 1] Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK [2] Department of Haematology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Bolli N; 1] Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK [2] Department of Haematology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Grove C; Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
Moody S; Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, UK.
Escudero-Ibarz L; Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, UK.
Gundem G; Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
Brugger K; Department of Molecular Genetics, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Xue X; Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, UK.
Mi E; Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, UK.
Bench A; Department of Haematology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Scott M; Department of Haematology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Liu H; Molecular Malignancy Laboratory, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Follows G; Department of Haematology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Robles EF; Division of Oncology, Center for Applied Medical Research CIMA, University of Navarra, Pamplona, Spain.
Martinez-Climent JA; Division of Oncology, Center for Applied Medical Research CIMA, University of Navarra, Pamplona, Spain.
Oscier D; Department of Haematology, Royal Bournemouth Hospital, Bournemouth, UK.
Watkins AJ; 1] Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, UK [2] Department of Haematology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Du MQ; Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, UK.

Leukemia ; 29(5): 1177-85, 2015 May.

Article em En | MEDLINE | ID: mdl-25428260

Assuntos

Fatores de Transcrição Kruppel-Like/genética; Linfoma de Zona Marginal Tipo Células B/genética; Mutação; Neoplasias Esplênicas/genética; Biópsia; Proteínas Adaptadoras de Sinalização CARD/metabolismo; Proteínas de Ligação a DNA/metabolismo; Exoma; Mutação da Fase de Leitura; Rearranjo Gênico de Cadeia Pesada de Linfócito B; Variação Genética; Genótipo; Guanilato Ciclase/metabolismo; Humanos; Peptídeos e Proteínas de Sinalização Intracelular/metabolismo; Linfoma/metabolismo; Linfoma de Zona Marginal Tipo Células B/diagnóstico; Mutação de Sentido Incorreto; Proteínas Nucleares/metabolismo; Reação em Cadeia da Polimerase; Receptor Notch2/metabolismo; Recidiva; Análise de Sequência de DNA; Transdução de Sinais; Neoplasias Esplênicas/diagnóstico; Proteína 3 Induzida por Fator de Necrose Tumoral alfa

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Esplênicas / Linfoma de Zona Marginal Tipo Células B / Fatores de Transcrição Kruppel-Like / Mutação Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Leukemia Assunto da revista: HEMATOLOGIA / NEOPLASIAS Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Reino Unido

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