Second-generation antipsychotic effect on cognition in patients with schizophrenia--a meta-analysis of randomized clinical trials.
Acta Psychiatr Scand
; 131(3): 185-96, 2015 Mar.
Article
em En
| MEDLINE
| ID: mdl-25597383
ABSTRACT
OBJECTIVE:
To investigate the effect of second-generation antipsychotics on cognitive function in patients diagnosed with schizophrenia or schizoaffective disorder.METHOD:
Multiple-treatments meta-analysis model.RESULTS:
On cognitive composite score, sertindole was superior to clozapine, effect size (ES) 0.87; 95% CI 0.12-1.63, quetiapine, ES 0.75; 95% CI 0.00-1.49, and first-generation antipsychotics (FGAs), ES 0.89; 95% CI 0.14-1.64. Analyses on each cognitive domain showed clozapine, ES 0.37; 95% CI 0.00-0.74, olanzapine, ES 0.31; 95%CI 0.02-0.59, quetiapine, ES 0.34; 95% CI 0.03-0.64, and FGAs, ES 0.51; 95% CI 0.18-0.83 performing poorer on verbal working memory than ziprasidone, as well as FGAs performing poorer than risperidone, ES 0.31; 95% CI 0.04-0.58. On executive function, sertindole performed better than clozapine, ES 0.82; 95% CI 0.06-1.58, olanzapine, ES 0.81; 95% CI 0.07-1.55, quetiapine, ES 0.76; 95% CI 0.02-1.51, ziprasidone, ES 0.90; 95% CI 0.14-1.67, and FGAs, ES 0.83; 95% CI 0.08-1.58. On processing speed, FGAs performed poorer than sertindole, ES 0.97; 95% CI 0.02-1.91, and quetiapine, ES 0.36; 95% CI 0.01-0.72. On long-term verbal working memory, clozapine performed poorer than olanzapine, ES 0.41; 95% CI 0.06-0.76. On verbal fluency, FGAs performed poorer than olanzapine, ES 0.26; 95% CI 0.01-0.50, and clozapine, ES 0.44; 95% CI 0.06-0.81. Lastly, FGAs, ES 0.41; 95% CI 0.04-0.78, and clozapine, ES 0.44; 95% CI 0.05-0.83, performed poorer on visuospatial skill compared to olanzapine.CONCLUSION:
The meta-analysis was able to detect some trends in the data analyzed, but did not show any drug having a uniform positive cognitive profile.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos Psicóticos
/
Esquizofrenia
/
Antipsicóticos
/
Cognição
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Acta Psychiatr Scand
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Dinamarca