Requirement for chloride channel function during the hepatitis C virus life cycle.
J Virol
; 89(7): 4023-9, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25609806
ABSTRACT
Hepatocytes express an array of plasma membrane and intracellular ion channels, yet their role during the hepatitis C virus (HCV) life cycle remains largely undefined. Here, we show that HCV increases intracellular hepatic chloride (Cl(-)) influx that can be inhibited by selective Cl(-) channel blockers. Through pharmacological and small interfering RNA (siRNA)-mediated silencing, we demonstrate that Cl(-) channel inhibition is detrimental to HCV replication. This represents the first observation of the involvement of Cl(-) channels during the HCV life cycle.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Canais de Cloreto
/
Hepacivirus
/
Hepatócitos
/
Interações Hospedeiro-Patógeno
Limite:
Humans
Idioma:
En
Revista:
J Virol
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Reino Unido