The Rif GTPase regulates cytoskeletal signaling from plexinA4 to promote neurite retraction.
Neurosci Lett
; 590: 178-83, 2015 Mar 17.
Article
em En
| MEDLINE
| ID: mdl-25668492
ABSTRACT
The small GTPase Rif is required for the early stages of dendritic spine formation in neurons, acting through the formin mDia2 to control actin polymerization. Rif is expressed at high levels in the brain, suggesting broader roles in neuronal function. We screened a yeast two-hybrid cDNA library to identify additional binding partners for Rif of potential relevance to neuronal function. We found that Rif interacts with FARP1, a neuronal activator of the RhoA GTPase. We show that Rif has two separate roles in FARP1 regulation-in controlling its association with plexinA4, and in releasing active RhoA from a plexinA4/FARP1 complex. The regulation of FARP1 by Rif promotes neurite retraction in cells stimulated with the semaphorin Sema6A.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Citoesqueleto
/
Neuritos
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Receptores de Superfície Celular
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Proteínas rho de Ligação ao GTP
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
China