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Design and mechanism of tetrahydrothiophene-based γ-aminobutyric acid aminotransferase inactivators.
Le, Hoang V; Hawker, Dustin D; Wu, Rui; Doud, Emma; Widom, Julia; Sanishvili, Ruslan; Liu, Dali; Kelleher, Neil L; Silverman, Richard B.
Afiliação
  • Le HV; †Departments of Chemistry and Molecular Biosciences, Chemistry of Life Processes Institute, and the Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, Illinois 60208, United States.
  • Hawker DD; †Departments of Chemistry and Molecular Biosciences, Chemistry of Life Processes Institute, and the Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, Illinois 60208, United States.
  • Wu R; ‡Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States.
  • Doud E; §Departments of Chemistry and Molecular Biosciences and the Proteomics Center of Excellence, Northwestern University, Evanston, Illinois 60208, United States.
  • Widom J; †Departments of Chemistry and Molecular Biosciences, Chemistry of Life Processes Institute, and the Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, Illinois 60208, United States.
  • Sanishvili R; ∥X-ray Science Division, Advanced Photon Source, Argonne National Laboratory, Lemont, Illinois 60439, United States.
  • Liu D; ‡Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States.
  • Kelleher NL; §Departments of Chemistry and Molecular Biosciences and the Proteomics Center of Excellence, Northwestern University, Evanston, Illinois 60208, United States.
  • Silverman RB; †Departments of Chemistry and Molecular Biosciences, Chemistry of Life Processes Institute, and the Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, Illinois 60208, United States.
J Am Chem Soc ; 137(13): 4525-33, 2015 Apr 08.
Article em En | MEDLINE | ID: mdl-25781189
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiofenos / Desenho de Fármacos / Inibidores Enzimáticos / 4-Aminobutirato Transaminase Idioma: En Revista: J Am Chem Soc Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiofenos / Desenho de Fármacos / Inibidores Enzimáticos / 4-Aminobutirato Transaminase Idioma: En Revista: J Am Chem Soc Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos