Biomarkers for lung epithelium injury in occupational hexavalent chromium-exposed workers.
J Occup Environ Med
; 57(4): e45-50, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25851191
ABSTRACT
OBJECTIVE:
To evaluate whether Club (Clara) cell protein (CC16) and surfactant-associated protein D (SP-D) can be used as biomarkers for lung injury caused by chromium exposure.METHODS:
The concentrations of chromium in the air (CrA), chromium in the blood (CrB), lung function, CC16, SP-D, tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) were detected in 91 chromium-exposed workers and 38 controls.RESULTS:
In chromium-exposed group, the levels of CrA, CrB, SP-D, TNF-α, and IL-6 were significantly higher, whereas forced expiratory volume in one second (FEV1), FEV1/FVC, maximal expiratory flow (MEF), maximum ventilation volume (MVV), CC16, and CC16/SP-D were lower. Negative correlations were shown between CC16, SP-D or CC16/SP-D, and CrB or inflammatory cytokines (TNF-α and IL-6). Positive relationships were shown between CC16 or CC16/SP-D with indicators of lung function. Tobacco smoking and chromium exposure had synergic effects on lung injury.CONCLUSIONS:
CC16, as an immunosuppressive protein, and CC16/SP-D can be used as sensitive and noninvasive biomarkers for lung injury. Smoking should be banned in chromium workplaces.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
2_ODS3
Problema de saúde:
2_quimicos_contaminacion
Assunto principal:
Uteroglobina
/
Cromo
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Exposição Ocupacional
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Proteína D Associada a Surfactante Pulmonar
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Poluentes Ocupacionais do Ar
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Lesão Pulmonar
Tipo de estudo:
Evaluation_studies
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Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Occup Environ Med
Assunto da revista:
MEDICINA OCUPACIONAL
/
SAUDE AMBIENTAL
Ano de publicação:
2015
Tipo de documento:
Article