A role for the small GTPase Rac1 in vaccinia actin-based motility.
Small GTPases
; 6(2): 119-22, 2015.
Article
em En
| MEDLINE
| ID: mdl-26147090
ABSTRACT
Vaccinia virus dissemination relies on the recruitment of the nucleation promoting factor N-WASP underneath cell-associated extracellular virus (CEVs) and subsequent recruitment and activation of the ARP2/3 complex, a major actin nucleator of the host cell. We have recently discovered that, in addition to the N-WASP/ARP2/3 pathway, vaccinia actin-based motility also relies on the small GTPase Rac1 and its downstream effector the formin-type actin nucleator FHOD1. Here we discuss the potential signaling mechanisms supporting the integration of the N-WASP/ARP2/3 and Rac1/FHOD1 pathways. We suggest the existence of a receptor tyrosine kinase family member that would integrate the Src-dependent activation of the N-WASP/ARP2/3 pathway and the GTP exchange factor-dependent activation of the Rac1/FHOD1 pathway.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vacínia
/
Vaccinia virus
/
Proteínas rac1 de Ligação ao GTP
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Liberação de Vírus
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Small GTPases
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Argentina