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"Brain MR spectroscopy in autism spectrum disorder-the GABA excitatory/inhibitory imbalance theory revisited".
Brix, Maiken K; Ersland, Lars; Hugdahl, Kenneth; Grüner, Renate; Posserud, Maj-Britt; Hammar, Åsa; Craven, Alexander R; Noeske, Ralph; Evans, C John; Walker, Hanne B; Midtvedt, Tore; Beyer, Mona K.
Afiliação
  • Brix MK; Department of Radiology, Haukeland University Hospital Bergen, Norway ; Department of Clinical Medicine (K1), University of Bergen Bergen, Norway.
  • Ersland L; Department of Clinical Engineering, Haukeland University Hospital Bergen, Norway ; NORMENT - KG Jebsen Center for Mental Disorders Research, University of Bergen Bergen, Norway.
  • Hugdahl K; Department of Radiology, Haukeland University Hospital Bergen, Norway ; NORMENT - KG Jebsen Center for Mental Disorders Research, University of Bergen Bergen, Norway ; Department of Biological and Medical Psychology, University of Bergen Bergen, Norway ; Division of Psychiatry, Haukeland University
  • Grüner R; Department of Radiology, Haukeland University Hospital Bergen, Norway ; NORMENT - KG Jebsen Center for Mental Disorders Research, University of Bergen Bergen, Norway ; Department of Physics and Technology, University of Bergen Bergen, Norway.
  • Posserud MB; Department of Child and Adolescent Psychiatry, Haukeland University Hospital Bergen, Norway.
  • Hammar Å; Department of Biological and Medical Psychology, University of Bergen Bergen, Norway.
  • Craven AR; NORMENT - KG Jebsen Center for Mental Disorders Research, University of Bergen Bergen, Norway ; Department of Biological and Medical Psychology, University of Bergen Bergen, Norway.
  • Noeske R; MR Applications and Workflow Development, GE Healthcare Berlin, Germany.
  • Evans CJ; CUBRIC, School of Psychology/Ysgol Seicoleg, Cardiff University/Prifysgol Caerdydd Wales Cardiff, UK.
  • Walker HB; Faculty of Mathematics and Natural Sciences, University of Oslo Oslo, Norway.
  • Midtvedt T; Department of Microbiology, Tumor and Cell Biology, Karolinska Institute Stockholm, Sweden.
  • Beyer MK; Department of Radiology and Nuclear Medicine, Oslo University Hospital Oslo, Norway ; Faculty of Health Sciences, Department of Life Sciences and Health, Oslo and Akershus University College of Applied Sciences Oslo, Norway.
Front Hum Neurosci ; 9: 365, 2015.
Article em En | MEDLINE | ID: mdl-26157380
ABSTRACT
Magnetic resonance spectroscopy (MRS) from voxels placed in the left anterior cingulate cortex (ACC) was measured from 14 boys with Autism Spectrum Disorder (ASD) and 24 gender and age-matched typically developing (TD) control group. Our main aims were to compare the concentration of γ-aminobutyric acid (GABA) between the two groups, and to investigate the relationship between brain metabolites and autism symptom severity in the ASD group. We did find a significant negative correlation in the ASD group between Autism Spectrum Screening Questionnaire (ASSQ) and GABA+/Cr, which may imply that severity of symptoms in ASD is associated with differences in the level of GABA in the brain, supporting the excitatory/inhibitory (E/I) imbalance theory. However we did not find a significant difference between the two groups in GABA levels.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Hum Neurosci Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Noruega
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Hum Neurosci Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Noruega