Heritability of ambulatory and office blood pressure in the Swiss population.
J Hypertens
; 33(10): 2061-7, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-26203966
ABSTRACT
BACKGROUND:
Blood pressure (BP) is known to aggregate in families. Yet, heritability estimates are population-specific and no Swiss data have been published so far. We estimated the heritability of ambulatory and office BP in a Swiss population-based sample.METHODS:
The Swiss Kidney Project on Genes in Hypertension is a population-based family study focusing on BP genetics. Office and ambulatory BP were measured in 1009 individuals from 271 nuclear families. Heritability was estimated for SBP, DBP, and pulse pressure using a maximum likelihood method implanted in the Statistical Analysis in Genetic Epidemiology software.RESULTS:
The 518 women and 491 men included in this analysis had a mean (±SD) age of 48.3 (±17.4) and 47.3 (±17.7) years, and a mean BMI of 23.8 (±4.2) and 25.9 (±4.1) kg/m, respectively. Narrow-sense heritability estimates (±standard error) for ambulatory SBP, DBP, and pulse pressure were 0.37â±â0.07, 0.26â±â0.07, and 0.29â±â0.07 for 24-h BP; 0.39â±â0.07, 0.28â±â0.07, and 0.27â±â0.07 for day BP; and 0.25â±â0.07, 0.20â±â0.07, and 0.30â±â0.07 for night BP, respectively (all Pâ<â0.001). Heritability estimates for office SBP, DBP, and pulse pressure were 0.21â±â0.08, 0.25â±â0.08, and 0.18â±â0.07 (all Pâ<â0.01).CONCLUSIONS:
We found significant heritability estimates for both ambulatory and office BP in this Swiss population-based study. Our findings justify the ongoing search for the genetic determinants of BP.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pressão Sanguínea
/
Hipertensão
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
J Hypertens
Ano de publicação:
2015
Tipo de documento:
Article