Toward a Better Understanding of the Physical Stability of Amorphous Anti-Inflammatory Agents: The Roles of Molecular Mobility and Molecular Interaction Patterns.

Rams-Baron, M; Wojnarowska, Z; Grzybowska, K; Dulski, M; Knapik, J; Jurkiewicz, K; Smolka, W; Sawicki, W; Ratuszna, A; Paluch, M

Rams-Baron, M; Wojnarowska, Z; Grzybowska, K; Dulski, M; Knapik, J; Jurkiewicz, K; Smolka, W; Sawicki, W; Ratuszna, A; Paluch, M.

Afiliação

Rams-Baron M; Institute of Physics, University of Silesia , Uniwersytecka 4, 40-007 Katowice, Poland.
Wojnarowska Z; Silesian Center for Education and Interdisciplinary Research, 75 Pulku Piechoty 1a, 41-500 Chorzów, Poland.
Grzybowska K; Institute of Physics, University of Silesia , Uniwersytecka 4, 40-007 Katowice, Poland.
Dulski M; Silesian Center for Education and Interdisciplinary Research, 75 Pulku Piechoty 1a, 41-500 Chorzów, Poland.
Knapik J; Institute of Physics, University of Silesia , Uniwersytecka 4, 40-007 Katowice, Poland.
Jurkiewicz K; Silesian Center for Education and Interdisciplinary Research, 75 Pulku Piechoty 1a, 41-500 Chorzów, Poland.
Smolka W; Institute of Material Sciences, University of Silesia , 75 Pulku Piechoty 1a, 41-500 Chorzów, Poland.
Sawicki W; Institute of Physics, University of Silesia , Uniwersytecka 4, 40-007 Katowice, Poland.
Ratuszna A; Silesian Center for Education and Interdisciplinary Research, 75 Pulku Piechoty 1a, 41-500 Chorzów, Poland.
Paluch M; Institute of Physics, University of Silesia , Uniwersytecka 4, 40-007 Katowice, Poland.

Mol Pharm ; 12(10): 3628-38, 2015 Oct 05.

Article em En | MEDLINE | ID: mdl-26323061

Assuntos

Anti-Inflamatórios/química; Celecoxib/química; Estabilidade de Medicamentos; Lactonas/química; Piridinas/química; Sulfonas/química; Cristalização; Espectroscopia Dielétrica; Etoricoxib

Palavras-chave

amorphous drug; hydrogen bonding; molecular dynamics; molecular interactions; physical stability; tautomerization

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Sulfonas / Estabilidade de Medicamentos / Celecoxib / Lactonas / Anti-Inflamatórios Idioma: En Revista: Mol Pharm Assunto da revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Polônia

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