Long-term immune reactivity to pre-S(2)-antigen after acute hepatitis B infection.
J Med Virol
; 27(2): 95-9, 1989 Feb.
Article
em En
| MEDLINE
| ID: mdl-2646395
ABSTRACT
We investigated sera from 39 patients, taken 1-8 years after recovery from acute hepatitis B for anti-pre-S(2) by Western blotting and for anti-HBs by radioimmunoassay. Anti-pre-S(2) antibodies were found in 27 out of 39 sera (69%) with the highest frequency in sera with anti-HBs greater than 100 IU/I (92%). However, sometimes sera with low anti-HBs titres showed a strong response in Western blotting. Acute hepatitis sera were also investigated from a limited number of patients (n = 14). Anti-pre-S(2) antibodies were found during antigenaemia (four out of six patients) and within 3 months after the maximum of alanine amino transferase (ALAT) (seven out of ten patients). Anti-pre-S(2) is an early antibody. It remains in the circulation for many years similar to but independent of anti-HBs.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Precursores de Proteínas
/
Proteínas do Envelope Viral
/
Hepatite B
/
Anticorpos Anti-Hepatite B
/
Antígenos de Superfície da Hepatite B
Limite:
Humans
Idioma:
En
Revista:
J Med Virol
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Holanda