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Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat.
Clemens, Laura E; Weber, Jonasz J; Wlodkowski, Tanja T; Yu-Taeger, Libo; Michaud, Magali; Calaminus, Carsten; Eckert, Schamim H; Gaca, Janett; Weiss, Andreas; Magg, Janine C D; Jansson, Erik K H; Eckert, Gunter P; Pichler, Bernd J; Bordet, Thierry; Pruss, Rebecca M; Riess, Olaf; Nguyen, Huu P.
Afiliação
  • Clemens LE; 1 Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany 2 Centre for Rare Diseases, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany.
  • Weber JJ; 1 Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany 2 Centre for Rare Diseases, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany.
  • Wlodkowski TT; 1 Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany 2 Centre for Rare Diseases, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany.
  • Yu-Taeger L; 1 Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany 2 Centre for Rare Diseases, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany.
  • Michaud M; 3 Trophos SA., Parc Scientifique de Luminy Case 931, 13288 Marseille Cedex 9, France.
  • Calaminus C; 4 Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, Roentgenweg 13, 72076 Tuebingen, Germany.
  • Eckert SH; 5 Department of Pharmacology, Goethe University Frankfurt am Main, Max-von-Laue Str. 9, 60438 Frankfurt, Germany.
  • Gaca J; 5 Department of Pharmacology, Goethe University Frankfurt am Main, Max-von-Laue Str. 9, 60438 Frankfurt, Germany.
  • Weiss A; 6 Novartis Institutes for BioMedical Research, Klybeckstrasse 141, 4057 Basel, Switzerland.
  • Magg JC; 1 Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany 2 Centre for Rare Diseases, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany.
  • Jansson EK; 1 Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany 2 Centre for Rare Diseases, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany.
  • Eckert GP; 5 Department of Pharmacology, Goethe University Frankfurt am Main, Max-von-Laue Str. 9, 60438 Frankfurt, Germany.
  • Pichler BJ; 4 Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, Roentgenweg 13, 72076 Tuebingen, Germany.
  • Bordet T; 3 Trophos SA., Parc Scientifique de Luminy Case 931, 13288 Marseille Cedex 9, France.
  • Pruss RM; 3 Trophos SA., Parc Scientifique de Luminy Case 931, 13288 Marseille Cedex 9, France.
  • Riess O; 1 Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany 2 Centre for Rare Diseases, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany.
  • Nguyen HP; 1 Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany 2 Centre for Rare Diseases, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany hoa.nguyen@med.uni-tuebingen.de.
Brain ; 138(Pt 12): 3632-53, 2015 Dec.
Article em En | MEDLINE | ID: mdl-26490331
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Calpaína / Colestenonas / Doença de Huntington / Proteínas Mutantes / Proteólise / Proteínas do Tecido Nervoso Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Brain Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Calpaína / Colestenonas / Doença de Huntington / Proteínas Mutantes / Proteólise / Proteínas do Tecido Nervoso Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Brain Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Alemanha