The relation of urinary bisphenol A with kisspeptin in girls diagnosed with central precocious puberty and premature thelarche.
J Pediatr Endocrinol Metab
; 29(3): 337-41, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-26565542
ABSTRACT
BACKGROUND:
Bisphenol A (BPA) is known as an endocrine disruptor and it is supposed to have a role on the development of central precocious puberty (CPP). Kisspeptin, a hypothalamic peptide, is a neuromodulator of gonadotropin releasing hormone and it has an important role on regulation of the onset of puberty. The BPA levels in girls with CPP and premature thelarche (PT) and its relation with kisspeptin levels were investigated.METHODS:
Twenty-eight girls with CPP, 28 girls with PT and 22 prepubertal girls as a control group were enrolled to the study. Urinary BPA and serum kisspeptin levels were compared in the groups. Bivariate correlations were performed to evaluate the relations of BPA with kisspeptin and estradiol.RESULTS:
There was no statistical difference between groups regarding BPA levels. Serum kisspeptin levels were higher in CPP group than controls [306.56 (interquartile range (IQR), 175.63-504.66) vs. 157.62 (IQR, 55.61-285.00) p 0.008]. There were no correlations between BPA and kisspeptin levels (r 0.088, p 0.391) and between BPA and estradiol (r -0.171, p 0.144).CONCLUSIONS:
The BPA levels did not differentiate between groups and it seems that the exposed amount of BPA in daily life did not affect kisspeptin levels in girls with CPP and PT.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenóis
/
Puberdade Precoce
/
Maturidade Sexual
/
Compostos Benzidrílicos
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Biomarcadores
/
Kisspeptinas
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limite:
Child
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Child, preschool
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Female
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Humans
/
Male
Idioma:
En
Revista:
J Pediatr Endocrinol Metab
Assunto da revista:
ENDOCRINOLOGIA
/
PEDIATRIA
Ano de publicação:
2016
Tipo de documento:
Article