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Nuclear magnetic resonance detection and spectroscopy of single proteins using quantum logic.
Lovchinsky, I; Sushkov, A O; Urbach, E; de Leon, N P; Choi, S; De Greve, K; Evans, R; Gertner, R; Bersin, E; Müller, C; McGuinness, L; Jelezko, F; Walsworth, R L; Park, H; Lukin, M D.
Afiliação
  • Lovchinsky I; Department of Physics, Harvard University, Cambridge, MA 02138, USA.
  • Sushkov AO; Department of Physics, Harvard University, Cambridge, MA 02138, USA. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
  • Urbach E; Department of Physics, Harvard University, Cambridge, MA 02138, USA.
  • de Leon NP; Department of Physics, Harvard University, Cambridge, MA 02138, USA. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
  • Choi S; Department of Physics, Harvard University, Cambridge, MA 02138, USA.
  • De Greve K; Department of Physics, Harvard University, Cambridge, MA 02138, USA.
  • Evans R; Department of Physics, Harvard University, Cambridge, MA 02138, USA.
  • Gertner R; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
  • Bersin E; Department of Physics, Harvard University, Cambridge, MA 02138, USA.
  • Müller C; Institute for Quantum Optics and Center for Integrated Quantum Science and Technology (IQST), Ulm University, D-89081, Ulm, Germany.
  • McGuinness L; Institute for Quantum Optics and Center for Integrated Quantum Science and Technology (IQST), Ulm University, D-89081, Ulm, Germany.
  • Jelezko F; Institute for Quantum Optics and Center for Integrated Quantum Science and Technology (IQST), Ulm University, D-89081, Ulm, Germany.
  • Walsworth RL; Department of Physics, Harvard University, Cambridge, MA 02138, USA. Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138, USA. Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
  • Park H; Department of Physics, Harvard University, Cambridge, MA 02138, USA. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA. Center for Brain Science, Harvard University, Cambridge, MA 02138, USA. Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge,
  • Lukin MD; Department of Physics, Harvard University, Cambridge, MA 02138, USA. lukin@physics.harvard.edu hongkun_park@harvard.edu.
Science ; 351(6275): 836-41, 2016 Feb 19.
Article em En | MEDLINE | ID: mdl-26847544
ABSTRACT
Nuclear magnetic resonance spectroscopy is a powerful tool for the structural analysis of organic compounds and biomolecules but typically requires macroscopic sample quantities. We use a sensor, which consists of two quantum bits corresponding to an electronic spin and an ancillary nuclear spin, to demonstrate room temperature magnetic resonance detection and spectroscopy of multiple nuclear species within individual ubiquitin proteins attached to the diamond surface. Using quantum logic to improve readout fidelity and a surface-treatment technique to extend the spin coherence time of shallow nitrogen-vacancy centers, we demonstrate magnetic field sensitivity sufficient to detect individual proton spins within 1 second of integration. This gain in sensitivity enables high-confidence detection of individual proteins and allows us to observe spectral features that reveal information about their chemical composition.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas / Ressonância Magnética Nuclear Biomolecular Tipo de estudo: Diagnostic_studies Idioma: En Revista: Science Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas / Ressonância Magnética Nuclear Biomolecular Tipo de estudo: Diagnostic_studies Idioma: En Revista: Science Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos