Copper-catalyzed three-component synthesis of aminonaphthoquinone-sulfonylamidine conjugates and in vitro evaluation of their antiproliferative activity.

Suja, Thachapully D; Divya, K V L; Naik, Lakshma V; Ravi Kumar, A; Kamal, Ahmed

Suja, Thachapully D; Divya, K V L; Naik, Lakshma V; Ravi Kumar, A; Kamal, Ahmed.

Afiliação

Suja TD; Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India. Electronic address: tdsuja.iict@gov.in.
Divya KV; Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India.
Naik LV; Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India.
Ravi Kumar A; Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Balanagar, Hyderabad 500 037, India.
Kamal A; Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Balanagar, Hyderabad 500 037, India.

Bioorg Med Chem Lett ; 26(8): 2072-6, 2016 Apr 15.

Article em En | MEDLINE | ID: mdl-26948541

Assuntos

Amidinas/farmacologia; Antineoplásicos/síntese química; Antineoplásicos/farmacologia; Cobre/química; Naftoquinonas/farmacologia; Amidinas/química; Antineoplásicos/química; Catálise; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Estrutura Molecular; Naftoquinonas/química; Relação Estrutura-Atividade

Palavras-chave

Aminonaphthoquinone; Copper; Multicomponent reactions; Sulfonylamidine; Topoisomerase inhibitor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Naftoquinonas / Cobre / Amidinas / Antineoplásicos Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2016 Tipo de documento: Article

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