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Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease.
Alfonso, Stephanie I; Callender, Julia A; Hooli, Basavaraj; Antal, Corina E; Mullin, Kristina; Sherman, Mathew A; Lesné, Sylvain E; Leitges, Michael; Newton, Alexandra C; Tanzi, Rudolph E; Malinow, Roberto.
Afiliação
  • Alfonso SI; Department of Neurosciences and Division of Biology, Section of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA.
  • Callender JA; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA. Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA.
  • Hooli B; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
  • Antal CE; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA. Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA.
  • Mullin K; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
  • Sherman MA; Department of Neuroscience, N. Bud Grossman Center for Memory Research and Care, and Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN 55414, USA.
  • Lesné SE; Department of Neuroscience, N. Bud Grossman Center for Memory Research and Care, and Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN 55414, USA.
  • Leitges M; Biotechnology Centre of Oslo, University of Oslo, Oslo 0317, Norway.
  • Newton AC; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA. anewton@ucsd.edu tanzi@helix.mgh.harvard.edu rmalinow@ucsd.edu.
  • Tanzi RE; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. anewton@ucsd.edu tanzi@helix.mgh.harvard.edu rmalinow@ucsd.edu.
  • Malinow R; Department of Neurosciences and Division of Biology, Section of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA. anewton@ucsd.edu tanzi@helix.mgh.harvard.edu rmalinow@ucsd.edu.
Sci Signal ; 9(427): ra47, 2016 05 10.
Article em En | MEDLINE | ID: mdl-27165780
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sinapses / Proteína Quinase C-alfa / Doença de Alzheimer / Mutação Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Sci Signal Assunto da revista: CIENCIA / FISIOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sinapses / Proteína Quinase C-alfa / Doença de Alzheimer / Mutação Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Sci Signal Assunto da revista: CIENCIA / FISIOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos