Macrophages Exhibit a Large Repertoire of Activation States via Multiple Mechanisms of Macrophage-activating Factors.
Anticancer Res
; 36(7): 3619-23, 2016 Jul.
Article
em En
| MEDLINE
| ID: mdl-27354632
ABSTRACT
BACKGROUND/AIM:
Macrophages are important components of human defense systems and consequently key to antitumor immunity. Human-serum macrophage activation factor (serum MAF) can activate macrophages, making it a promising reagent for anticancer therapy. MATERIALS ANDMETHODS:
We established four different macrophage subtypes through introduction of different culture conditions to THP-1- and U937-derived macrophages. We assessed phagocytic activity to understand subtype responses to typical macrophage activation factors (MAFs) and the activation mechanisms of serum MAF.RESULTS:
All four macrophage subtypes differed in their response to all MAFs. Moreover, serum MAF had two different activation mechanisms N-acetylgalactosamine (GalNAc)-dependent and GalNAc-independent.CONCLUSION:
Macrophage activation states and mechanisms are heterogeneous.Palavras-chave
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores Ativadores de Macrófagos
/
Ativação de Macrófagos
/
Macrófagos
Limite:
Humans
Idioma:
En
Revista:
Anticancer Res
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Japão