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A Novel Allosteric Activator of Free Fatty Acid 2 Receptor Displays Unique Gi-functional Bias.
Bolognini, Daniele; Moss, Catherine E; Nilsson, Karolina; Petersson, Annika U; Donnelly, Iona; Sergeev, Eugenia; König, Gabriele M; Kostenis, Evi; Kurowska-Stolarska, Mariola; Miller, Ashley; Dekker, Niek; Tobin, Andrew B; Milligan, Graeme.
Afiliação
  • Bolognini D; From the Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom.
  • Moss CE; From the Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom, the Medical Research Council Toxicology Unit, University of Leicester, Leicester LE1 9
  • Nilsson K; the Cardiovascular and Metabolic Diseases.
  • Petersson AU; Respiratory, Inflammatory and Autoimmune Diseases Innovative Medicines and Early Development Biotech Unit, Department of Medicinal Chemistry, and.
  • Donnelly I; the Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom.
  • Sergeev E; From the Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom.
  • König GM; Institute of Pharmaceutical Biology, University of Bonn, 53115 Bonn, Germany, and.
  • Kostenis E; the Molecular, Cellular and Pharmacobiology Section.
  • Kurowska-Stolarska M; the Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom.
  • Miller A; the Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom.
  • Dekker N; the Discovery Sciences, Reagents and Assay Development, AstraZeneca, Mölndal, Pepparedsleden 1, SE-431 83, Mölndal, Sweden.
  • Tobin AB; From the Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom, the Medical Research Council Toxicology Unit, University of Leicester, Leicester LE1 9
  • Milligan G; From the Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom, Graeme.Milligan@glasgow.ac.uk.
J Biol Chem ; 291(36): 18915-31, 2016 09 02.
Article em En | MEDLINE | ID: mdl-27385588
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Superfície Celular / Subunidades alfa Gi-Go de Proteínas de Ligação ao GTP / Sistema de Sinalização das MAP Quinases / Subunidades alfa Gq-G11 de Proteínas de Ligação ao GTP / Receptores Acoplados a Proteínas G / Depsipeptídeos Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Superfície Celular / Subunidades alfa Gi-Go de Proteínas de Ligação ao GTP / Sistema de Sinalização das MAP Quinases / Subunidades alfa Gq-G11 de Proteínas de Ligação ao GTP / Receptores Acoplados a Proteínas G / Depsipeptídeos Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Reino Unido