Cardiorespiratory activity of C-terminal pentapeptide of substance P in anaesthetized rats.
Respir Physiol Neurobiol
; 233: 7-13, 2016 11.
Article
em En
| MEDLINE
| ID: mdl-27453558
ABSTRACT
Experiments were performed in anaesthetized, spontaneously breathing rats to (1) analyse the respiratory and cardiovascular effects of C-terminal fragment of substance P (AWL2077) as referred to those exerted by the parent undecapeptide, (2) determine the involvement of lung vagal afferents to these responses. Each peptide was injected intravenously at a dose of 0.3µmol/kg into neurally intact or midcervically vagotomized rats. Administration of both compounds decreased tidal volume, minute ventilation, mean arterial blood pressure and heart rate, showing stimulatory (SP) and depressive (AWL2077) effects on the rate of breathing. Midcervical vagotomy reversed (post-SP) and precluded (post-AWL2077) respiratory rate responses and eliminated bradycardia evoked by both peptides. These findings indicate that the examined C-terminal pentapeptide was convergent with, but less potent than substance P in central depression of tidal volume and displayed divergence in the peripheral effect on respiratory timing.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Respiração
/
Pressão Sanguínea
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Substância P
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Frequência Cardíaca
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Anestesia
Limite:
Animals
Idioma:
En
Revista:
Respir Physiol Neurobiol
Ano de publicação:
2016
Tipo de documento:
Article