Efficient synthesis and antioxidant activities of N-heterocyclyl substituted Coenzyme Q analogues.
Bioorg Chem
; 68: 214-8, 2016 10.
Article
em En
| MEDLINE
| ID: mdl-27561631
ABSTRACT
A new strategy for the efficient synthesis of C-5 heterocyclyl substituted Coenzyme Q analogues was developed by N-alkylation of bromomethylated quinone 11 with a series of amines 12 under metal-free conditions. In vitro antioxidant activities of these Coenzyme Q analogues were evaluated and compared with commercial antioxidant Coenzyme Q10 by employing DPPH assay. All these N-heterocyclyl substituted Coenzyme Q analogues are found to be exhibiting good antioxidant properties and may be used as potent antioxidants for combating oxidative stress.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ubiquinona
/
Compostos Heterocíclicos
/
Antioxidantes
Idioma:
En
Revista:
Bioorg Chem
Ano de publicação:
2016
Tipo de documento:
Article