Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice.

Merry, Troy L; Tran, Melanie; Dodd, Garron T; Mangiafico, Salvatore P; Wiede, Florian; Kaur, Supreet; McLean, Catriona L; Andrikopoulos, Sofianos; Tiganis, Tony

Merry, Troy L; Tran, Melanie; Dodd, Garron T; Mangiafico, Salvatore P; Wiede, Florian; Kaur, Supreet; McLean, Catriona L; Andrikopoulos, Sofianos; Tiganis, Tony.

Afiliação

Merry TL; Metabolic Disease and Obesity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.
Tran M; Faculty of Medical and Health Sciences, The University of Auckland, Aukland, New Zealand.
Dodd GT; Metabolic Disease and Obesity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.
Mangiafico SP; Metabolic Disease and Obesity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.
Wiede F; Department of Medicine (Austin Hospital), The University of Melbourne, Melbourne, VIC, Australia.
Kaur S; Metabolic Disease and Obesity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.
McLean CL; Metabolic Disease and Obesity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.
Andrikopoulos S; Department of Anatomical Pathology, Alfred Hospital, Prahran, VIC, Australia.
Tiganis T; Department of Medicine (Austin Hospital), The University of Melbourne, Melbourne, VIC, Australia.

Diabetologia ; 59(12): 2632-2644, 2016 12.

Article em En | MEDLINE | ID: mdl-27628106

Assuntos

Fígado Gorduroso/metabolismo; Glucose/metabolismo; Glutationa Peroxidase/deficiência; Glutationa Peroxidase/metabolismo; Fígado/metabolismo; Hepatopatia Gordurosa não Alcoólica/enzimologia; Hepatopatia Gordurosa não Alcoólica/metabolismo; Alelos; Animais; Diabetes Mellitus Tipo 2/enzimologia; Diabetes Mellitus Tipo 2/metabolismo; Hepatócitos/metabolismo; Peróxido de Hidrogênio/metabolismo; Resistência à Insulina/fisiologia; Fígado/patologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Reação em Cadeia da Polimerase; Proteínas Tirosina Fosfatases/genética; Proteínas Tirosina Fosfatases/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Glutationa Peroxidase GPX1

Palavras-chave

Fibrosis; Glutathione peroxidase-1; Hepatocyte; Inflammation; Insulin resistance; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Protein tyrosine phosphatase; Reactive oxygen species; Type 2 diabetes

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fígado Gorduroso / Hepatopatia Gordurosa não Alcoólica / Glucose / Glutationa Peroxidase / Fígado Limite: Animals Idioma: En Revista: Diabetologia Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Austrália

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