[New prognostic and predictive markers for breast cancer]. / Neue prognostische und prädiktive Marker beim Mammakarzinom.
Pathologe
; 37(Suppl 2): 217-222, 2016 Nov.
Article
em De
| MEDLINE
| ID: mdl-27638528
ABSTRACT
Breast cancer can be divided into four molecular subtypes with different prognoses using immunohistochemical markers in the routine clinicopathological work-up. The protein Ki-67 is of central importance in this context, in particular to distinguish between luminal A and luminal B carcinomas. Determination of the Ki-67 index of a carcinoma also allows a prediction of the likelihood of the response to chemotherapy. Additionally, the expression of certain cytokeratins in tumor cells is associated with a poor response to chemotherapy. The heterogeneity of molecular subtypes with regard to the histological appearance indicates an even greater diversity of breast cancer. We were able to show that a high proportion of luminal B carcinomas display neuroendocrine differentiation. Further studies with particular emphasis on histomorphological criteria should be performed to attain a more accurate classification of breast cancer and to pave the way towards targeted therapies for a better prognosis in the future.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Mama
/
Neoplasias da Mama
/
Biomarcadores Tumorais
/
Transformação Celular Neoplásica
/
Tumores Neuroendócrinos
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
Idioma:
De
Revista:
Pathologe
Ano de publicação:
2016
Tipo de documento:
Article