Afatinib down-regulates MCL-1 expression through the PERK-eIF2&#945;-ATF4 axis and leads to apoptosis in head and neck squamous cell carcinoma.

Liu, Xianfang; Lv, Zhenghua; Zou, Jidong; Liu, Xiuxiu; Ma, Juke; Wang, Jinhua; Sa, Na; Jing, Peihang; Xu, Wei

Afatinib down-regulates MCL-1 expression through the PERK-eIF2α-ATF4 axis and leads to apoptosis in head and neck squamous cell carcinoma.

Liu, Xianfang; Lv, Zhenghua; Zou, Jidong; Liu, Xiuxiu; Ma, Juke; Wang, Jinhua; Sa, Na; Jing, Peihang; Xu, Wei.

Afiliação

Liu X; Department of Otorhinolaryngology Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong UniversityJinan, P. R. China; Shandong Provincial Key Laboratory of OtologyJinan, P. R. China.
Lv Z; Department of Otorhinolaryngology Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong University Jinan, P. R. China.
Zou J; Department of Otorhinolaryngology Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong University Jinan, P. R. China.
Liu X; Department of Otorhinolaryngology Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong UniversityJinan, P. R. China; Shandong Provincial Key Laboratory of OtologyJinan, P. R. China.
Ma J; Department of Otorhinolaryngology Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong University Jinan, P. R. China.
Wang J; Department of Otorhinolaryngology Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong University Jinan, P. R. China.
Sa N; Department of Otorhinolaryngology Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong University Jinan, P. R. China.
Jing P; Department of Otorhinolaryngology Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong University Jinan, P. R. China.
Xu W; Department of Otorhinolaryngology Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong UniversityJinan, P. R. China; Shandong Provincial Key Laboratory of OtologyJinan, P. R. China.

Am J Cancer Res ; 6(8): 1708-19, 2016.

Article em En | MEDLINE | ID: mdl-27648360

Palavras-chave

ATF4; Afatinib; MCL-1; PERK; apoptosis; eIF2α

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Am J Cancer Res Ano de publicação: 2016 Tipo de documento: Article