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A phase I, pharmacokinetic and pharmacodynamic study of GSK2256098, a focal adhesion kinase inhibitor, in patients with advanced solid tumors.
Soria, J C; Gan, H K; Blagden, S P; Plummer, R; Arkenau, H T; Ranson, M; Evans, T R J; Zalcman, G; Bahleda, R; Hollebecque, A; Lemech, C; Dean, E; Brown, J; Gibson, D; Peddareddigari, V; Murray, S; Nebot, N; Mazumdar, J; Swartz, L; Auger, K R; Fleming, R A; Singh, R; Millward, M.
Afiliação
  • Soria JC; Drug Development Department at Gustave Roussy Cancer Campus, University Paris-Sud, Paris, France soria@igr.fr.
  • Gan HK; Olivia Newton-John Cancer Research Institute, Austin Health, Melbourne, Australia.
  • Blagden SP; School of Cancer Medicine, Latrobe University, Melbourne, Australia.
  • Plummer R; Imperial College, Hammersmith Hospital, London.
  • Arkenau HT; Northern Centre for Cancer Care, Newcastle.
  • Ranson M; Sarah Cannon Research Institute, London.
  • Evans TR; University of Manchester, Christie Hospital, Manchester.
  • Zalcman G; University of Glasgow, Beatson West of Scotland Cancer Centre, Glasgow, UK.
  • Bahleda R; Early Phases Clinical Trials Unit at Caen University Hospital, Caen, France.
  • Hollebecque A; Drug Development Department at Gustave Roussy Cancer Campus, University Paris-Sud, Paris, France.
  • Lemech C; Drug Development Department at Gustave Roussy Cancer Campus, University Paris-Sud, Paris, France.
  • Dean E; Sarah Cannon Research Institute, London.
  • Brown J; University of Manchester, Christie Hospital, Manchester.
  • Gibson D; University of Glasgow, Beatson West of Scotland Cancer Centre, Glasgow, UK.
  • Peddareddigari V; GlaxoSmithKline, Research Triangle Park, NC and Upper Providence, Collegeville, USA.
  • Murray S; GlaxoSmithKline, Research Triangle Park, NC and Upper Providence, Collegeville, USA.
  • Nebot N; GlaxoSmithKline, Research Triangle Park, NC and Upper Providence, Collegeville, USA.
  • Mazumdar J; GlaxoSmithKline, Research Triangle Park, NC and Upper Providence, Collegeville, USA.
  • Swartz L; GlaxoSmithKline, Research Triangle Park, NC and Upper Providence, Collegeville, USA.
  • Auger KR; GlaxoSmithKline, Research Triangle Park, NC and Upper Providence, Collegeville, USA.
  • Fleming RA; GlaxoSmithKline, Research Triangle Park, NC and Upper Providence, Collegeville, USA.
  • Singh R; GlaxoSmithKline, Research Triangle Park, NC and Upper Providence, Collegeville, USA.
  • Millward M; GlaxoSmithKline, Research Triangle Park, NC and Upper Providence, Collegeville, USA.
Ann Oncol ; 27(12): 2268-2274, 2016 12.
Article em En | MEDLINE | ID: mdl-27733373

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 3_ND Problema de saúde: 3_diarrhea Assunto principal: Inibidores de Proteínas Quinases / Proteína-Tirosina Quinases de Adesão Focal / Aminopiridinas / Ácidos Hidroxâmicos / Neoplasias Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2016 Tipo de documento: Article País de afiliação: França

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 3_ND Problema de saúde: 3_diarrhea Assunto principal: Inibidores de Proteínas Quinases / Proteína-Tirosina Quinases de Adesão Focal / Aminopiridinas / Ácidos Hidroxâmicos / Neoplasias Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2016 Tipo de documento: Article País de afiliação: França
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