WZB117 (2-Fluoro-6-(m-hydroxybenzoyloxy) Phenyl m-Hydroxybenzoate) Inhibits GLUT1-mediated Sugar Transport by Binding Reversibly at the Exofacial Sugar Binding Site.

Ojelabi, Ogooluwa A; Lloyd, Kenneth P; Simon, Andrew H; De Zutter, Julie K; Carruthers, Anthony

Ojelabi, Ogooluwa A; Lloyd, Kenneth P; Simon, Andrew H; De Zutter, Julie K; Carruthers, Anthony.

Afiliação

Ojelabi OA; From the Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605.
Lloyd KP; From the Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605.
Simon AH; From the Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605.
De Zutter JK; From the Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605.
Carruthers A; From the Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605 anthony.carruthers@umassmed.edu.

J Biol Chem ; 291(52): 26762-26772, 2016 Dec 23.

Article em En | MEDLINE | ID: mdl-27836974

Assuntos

3-O-Metilglucose/metabolismo; Eritrócitos/metabolismo; Transportador de Glucose Tipo 1/metabolismo; Glucose/metabolismo; Hidroxibenzoatos/farmacologia; Animais; Sítios de Ligação; Transporte Biológico; Cristalografia por Raios X; Citocalasina B/metabolismo; Eritrócitos/efeitos dos fármacos; Transportador de Glucose Tipo 1/química; Transportador de Glucose Tipo 3/química; Transportador de Glucose Tipo 3/metabolismo; Transportador de Glucose Tipo 4/química; Transportador de Glucose Tipo 4/metabolismo; Células HEK293; Humanos; Cinética; Camundongos; Simulação de Acoplamento Molecular; Conformação Proteica

Palavras-chave

competitive inhibition; facilitated diffusion; glucose transport; ligand binding; ligand-binding protein; membrane transport; membrane transport protein; molecular docking; protein structure

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: 3-O-Metilglucose / Eritrócitos / Transportador de Glucose Tipo 1 / Glucose / Hidroxibenzoatos Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2016 Tipo de documento: Article

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