Sequence homology of a canine brain calcium-binding protein with calregulin and the human Ro/SS-A antigen.
Biochem Biophys Res Commun
; 164(1): 575-9, 1989 Oct 16.
Article
em En
| MEDLINE
| ID: mdl-2803321
ABSTRACT
A 60 kDa calcium-binding protein (CBP) was purified from canine brain and its N-terminal sequence determined to be Glu-Pro-Ala-Ile-Tyr-Phe-Lys-Glu-Gln-Phe-Leu-Asp-Gly-Asp-Gly-X-Thr-Arg-X- Ile- Glu-Ser-Lys. This sequence is very similar to that of "Ccalregulin", a CBP of unknown function which is similar in size and appears to be present in most animal tissues. An unexpected and even more striking similarity was found with the N-terminal sequence of the human Ro/SS-A antigen, a 60 kDa protein which has long been implicated in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus. These findings suggest that the Ro/SS-A antigen is probably also a CBP.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ribonucleoproteínas
/
Autoantígenos
/
Encéfalo
/
Proteínas de Ligação ao Cálcio
/
Sequência de Bases
/
Homologia de Sequência do Ácido Nucleico
/
RNA Citoplasmático Pequeno
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
1989
Tipo de documento:
Article