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Oncogenic BRAF fusions in mucosal melanomas activate the MAPK pathway and are sensitive to MEK/PI3K inhibition or MEK/CDK4/6 inhibition.
Kim, H S; Jung, M; Kang, H N; Kim, H; Park, C-W; Kim, S-M; Shin, S J; Kim, S H; Kim, S G; Kim, E K; Yun, M R; Zheng, Z; Chung, K Y; Greenbowe, J; Ali, S M; Kim, T-M; Cho, B C.
Afiliação
  • Kim HS; Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.
  • Jung M; Department of Pharmacology, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.
  • Kang HN; Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.
  • Kim H; JEUK Institute for Cancer Research, JEUK Co., Ltd., Gumi-City, Kyungbuk, Korea.
  • Park CW; JEUK Institute for Cancer Research, JEUK Co., Ltd., Gumi-City, Kyungbuk, Korea.
  • Kim SM; JEUK Institute for Cancer Research, JEUK Co., Ltd., Gumi-City, Kyungbuk, Korea.
  • Shin SJ; JEUK Institute for Cancer Research, JEUK Co., Ltd., Gumi-City, Kyungbuk, Korea.
  • Kim SH; Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.
  • Kim SG; Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
  • Kim EK; Anatomic Pathology Reference Lab, Seegene Medical Foundation, Seoul, Korea.
  • Yun MR; JEUK Institute for Cancer Research, JEUK Co., Ltd., Gumi-City, Kyungbuk, Korea.
  • Zheng Z; Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
  • Chung KY; JEUK Institute for Cancer Research, JEUK Co., Ltd., Gumi-City, Kyungbuk, Korea.
  • Greenbowe J; Department of Dermatology, Yanbian University Hospital, Yanji City, China.
  • Ali SM; Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea.
  • Kim TM; Foundation Medicine Inc., Cambridge, MA, USA.
  • Cho BC; Foundation Medicine Inc., Cambridge, MA, USA.
Oncogene ; 36(23): 3334-3345, 2017 06 08.
Article em En | MEDLINE | ID: mdl-28092667
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Fusão Oncogênica / Proteínas Quinases Ativadas por Mitógeno / Proteínas Proto-Oncogênicas B-raf / MAP Quinase Quinase 1 / Quinase 4 Dependente de Ciclina / Quinase 6 Dependente de Ciclina / Inibidores de Fosfoinositídeo-3 Quinase / Melanoma / Mucosa Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Revista: Oncogene Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Fusão Oncogênica / Proteínas Quinases Ativadas por Mitógeno / Proteínas Proto-Oncogênicas B-raf / MAP Quinase Quinase 1 / Quinase 4 Dependente de Ciclina / Quinase 6 Dependente de Ciclina / Inibidores de Fosfoinositídeo-3 Quinase / Melanoma / Mucosa Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Revista: Oncogene Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2017 Tipo de documento: Article