Dietary Fat Consumption and Non-Hodgkin's Lymphoma Risk: A Meta-analysis.
Nutr Cancer
; 69(2): 221-228, 2017.
Article
em En
| MEDLINE
| ID: mdl-28094569
ABSTRACT
OBJECTIVE:
Many studies suggest that high-fat diets are linked to the etiology of non-Hodgkin's lymphoma (NHL). However, the findings are inconsistent and therefore the association between fat and non-Hodgkin's lymphoma remains unclear. In this study, we aim to quantitatively assess the association between fat consumption and the risk for NHL.METHODS:
We reviewed 221 published cohort and case-control studies that reported relative risk (RRs) and corresponding 95% confidence intervals (CIs) of NHL and fat intake using PubMed, Cochrane, EMBASE, and Google Scholar databases. A random-effects model computed summary risk estimates.RESULTS:
Based on our literature search, 10 of 221 studies (two cohort and eight case-control studies) were relevant to this meta-analysis. There was a significant association between total fat consumption and increased risk of NHL (RR = 1.26; 95% CI 1.12-1.42); in addition, subgroup analysis showed a significant correlation with diffuse large B-cell lymphoma (RR = 1.41; 95% CI 1.08-1.84) but not with follicular lymphoma (RR = 1.21; 95% CI 0.97-1.52), small lymphocytic lymphoma/chronic lymphocytic leukemia (RR = 0.91; 95% CI 0.68-1.23), nor with T cell lymphoma (RR = 1.12; 95% CI 0.60-2.09). The funnel plot revealed no evidence for publication bias.CONCLUSION:
Total fat consumption, particularly animal fat, increases the risk for NHL.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfoma não Hodgkin
/
Gorduras na Dieta
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nutr Cancer
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
China