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The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.
He, Yupeng; Selvaraju, Sujatha; Curtin, Michael L; Jakob, Clarissa G; Zhu, Haizhong; Comess, Kenneth M; Shaw, Bailin; The, Juliana; Lima-Fernandes, Evelyne; Szewczyk, Magdalena M; Cheng, Dong; Klinge, Kelly L; Li, Huan-Qiu; Pliushchev, Marina; Algire, Mikkel A; Maag, David; Guo, Jun; Dietrich, Justin; Panchal, Sanjay C; Petros, Andrew M; Sweis, Ramzi F; Torrent, Maricel; Bigelow, Lance J; Senisterra, Guillermo; Li, Fengling; Kennedy, Steven; Wu, Qin; Osterling, Donald J; Lindley, David J; Gao, Wenqing; Galasinski, Scott; Barsyte-Lovejoy, Dalia; Vedadi, Masoud; Buchanan, Fritz G; Arrowsmith, Cheryl H; Chiang, Gary G; Sun, Chaohong; Pappano, William N.
Afiliação
  • He Y; AbbVie Inc., North Chicago, Illinois, USA.
  • Selvaraju S; AbbVie Inc., North Chicago, Illinois, USA.
  • Curtin ML; AbbVie Inc., North Chicago, Illinois, USA.
  • Jakob CG; AbbVie Inc., North Chicago, Illinois, USA.
  • Zhu H; AbbVie Inc., North Chicago, Illinois, USA.
  • Comess KM; AbbVie Inc., North Chicago, Illinois, USA.
  • Shaw B; AbbVie Inc., North Chicago, Illinois, USA.
  • The J; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Lima-Fernandes E; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Szewczyk MM; Princess Margaret Cancer Centre, and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
  • Cheng D; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Klinge KL; AbbVie Inc., North Chicago, Illinois, USA.
  • Li HQ; AbbVie Inc., North Chicago, Illinois, USA.
  • Pliushchev M; AbbVie Inc., North Chicago, Illinois, USA.
  • Algire MA; AbbVie Inc., North Chicago, Illinois, USA.
  • Maag D; AbbVie Inc., North Chicago, Illinois, USA.
  • Guo J; AbbVie Inc., North Chicago, Illinois, USA.
  • Dietrich J; AbbVie Inc., North Chicago, Illinois, USA.
  • Panchal SC; AbbVie Inc., North Chicago, Illinois, USA.
  • Petros AM; AbbVie Inc., North Chicago, Illinois, USA.
  • Sweis RF; AbbVie Inc., North Chicago, Illinois, USA.
  • Torrent M; AbbVie Inc., North Chicago, Illinois, USA.
  • Bigelow LJ; AbbVie Inc., North Chicago, Illinois, USA.
  • Senisterra G; AbbVie Inc., North Chicago, Illinois, USA.
  • Li F; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Kennedy S; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Wu Q; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Osterling DJ; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Lindley DJ; Princess Margaret Cancer Centre, and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
  • Gao W; AbbVie Inc., North Chicago, Illinois, USA.
  • Galasinski S; AbbVie Inc., North Chicago, Illinois, USA.
  • Barsyte-Lovejoy D; AbbVie Inc., North Chicago, Illinois, USA.
  • Vedadi M; AbbVie Inc., North Chicago, Illinois, USA.
  • Buchanan FG; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Arrowsmith CH; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Chiang GG; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
  • Sun C; AbbVie Inc., North Chicago, Illinois, USA.
  • Pappano WN; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
Nat Chem Biol ; 13(4): 389-395, 2017 04.
Article em En | MEDLINE | ID: mdl-28135237
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonamidas / Complexo Repressor Polycomb 2 / Indanos / Antineoplásicos Limite: Humans Idioma: En Revista: Nat Chem Biol Assunto da revista: BIOLOGIA / QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonamidas / Complexo Repressor Polycomb 2 / Indanos / Antineoplásicos Limite: Humans Idioma: En Revista: Nat Chem Biol Assunto da revista: BIOLOGIA / QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos