Variant Creutzfeldt-Jakob disease deferral in Canada: impact of stop dates.
Blood Transfus
; 16(1): 26-31, 2018 01.
Article
em En
| MEDLINE
| ID: mdl-28151391
ABSTRACT
BACKGROUND:
To reduce the risk of variant Creutzfeldt-Jakob disease (vCJD) transmission via blood transfusion in Canada, potential donors who spent a cumulative time in the United Kingdom, Western Europe or Saudi Arabia are deferred. "Stop dates" for accumulated time were later implemented for 3 months spent in the United Kingdom or France (1980-1996) and for 5 years elsewhere in Western Europe (1980-2007); Saudi Arabia deferral was implemented with the "stop date" (1980-1996). We evaluated the long-term impact of these deferrals and "stop dates", as well as the consistency of donors' answers to post-implementation screening questions. MATERIALS ANDMETHODS:
The monthly deferral rate was monitored from 2003-2015. Time series methods (ARIMA) were used with interruption when "stop dates" were implemented. A telephone survey of 1,000 donors (250 first-time, 500 repeat deferred donors, 250 non-deferred control donors) assessed travel history (response rate 62%). An anonymous mail survey of 40,000 donors assessed compliance with deferral (response rate 45.3%).RESULTS:
When the "stop date" for UK/France travel was implemented, the deferral rate decreased for first-time (2.1% to 1.1%, p<0.0001) and repeat (0.2% to 0.03%, p<0.0001) donors. The deferral rate increased after Saudi Arabia was included (mean increase of 0.4% first-time, 0.02% repeat, p<0.0001). After the Western Europe "stop date" the deferral rate was unchanged in first-time donors (1.0% to 1.1%, p=0.5) but decreased in repeat donors (0.03% to 0.02%, p<0.002). In the telephone survey, 94% of deferred donors confirmed deferrable travel history. In the anonymous survey 0.3% of donors were non-compliant with the UK/France deferral.DISCUSSION:
Donors, particularly first-time ones, continue to be lost due to vCJD travel deferral, but most deferrals are correctly applied and non-compliance is rare. The application of a "stop date" reduced deferrals for UK/France travel, but it may be too early to see the full impact of the "stop date" for Western Europe.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Creutzfeldt-Jakob
/
Seleção do Doador
Limite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Blood Transfus
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Canadá