OnabotulinumtoxinA in urinary incontinence: Prospective Study of a Case Series. / Onabotulinumtoxin A en la incontinencia urinaria: estudio prospectivo de serie de casos.
Actas Urol Esp
; 41(7): 458-464, 2017 Sep.
Article
em En, Es
| MEDLINE
| ID: mdl-28196743
ABSTRACT
OBJECTIVE:
To assess the safety and efficacy of a single intravesical injection of onabotulinumtoxinA (OnaBTA) for treating urge urinary incontinence (UUI) in women.METHOD:
We performed a prospective case-series study of consecutive patients with refractory UUI treated with an intravesical injection of OnaBTA. The patients were administered 100 units of OnaBTA injected into the bladder wall following 4 weeks of flushing with anticholinergic agents or beta 3 agonists. The urodynamic and clinical endpoints were evaluated before and 6 months after the injection of OnaBTA. The primary study endpoint was the number of episodes of urinary leakage.RESULTS:
A total of 204 of the 210 selected patients conducted a valid visit 6 months after the therapeutic application. At 6 months of treatment with OnaBTA, 110 (53.9%) patients remained continent and were considered a success. However, 57 (27.9%) patients experienced one episode of urinary leakage per day, and 37 (18.2%) had 2 or more. In terms of the urodynamic parameters, we observed the following changes increase in maximum bladder capacity (P<.0001) and reduced maximum pressure of the detrusor (P<.0001). In terms of the safety profile, 8 (3.9%) patients had self-limiting haematuria during the procedure, which resolved spontaneously, and 9 (4.4%) patients had acute urinary retention that required intermittent catheterisation.CONCLUSIONS:
This study supports the use of OnabotulinumtoxinA in patients with urge urinary incontinence that does not respond to medical treatment.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Toxinas Botulínicas Tipo A
/
Inibidores da Liberação da Acetilcolina
Tipo de estudo:
Observational_studies
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
/
Es
Revista:
Actas Urol Esp
Ano de publicação:
2017
Tipo de documento:
Article