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Usp9x regulates Ets-1 ubiquitination and stability to control NRAS expression and tumorigenicity in melanoma.
Potu, Harish; Peterson, Luke F; Kandarpa, Malathi; Pal, Anupama; Sun, Hanshi; Durham, Alison; Harms, Paul W; Hollenhorst, Peter C; Eskiocak, Ugur; Talpaz, Moshe; Donato, Nicholas J.
Afiliação
  • Potu H; Department of Internal Medicine/Division of Hematology/Oncology, University of Michigan School of Medicine and Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA.
  • Peterson LF; Department of Internal Medicine/Division of Hematology/Oncology, University of Michigan School of Medicine and Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA.
  • Kandarpa M; Department of Internal Medicine/Division of Hematology/Oncology, University of Michigan School of Medicine and Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA.
  • Pal A; Department of Internal Medicine/Division of Hematology/Oncology, University of Michigan School of Medicine and Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA.
  • Sun H; Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan 48109, USA.
  • Durham A; Department of Dermatology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA.
  • Harms PW; Departments of Pathology and Dermatology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA.
  • Hollenhorst PC; Department of Biochemistry and Molecular Biology, Medical Sciences Program, Indiana University Bloomington, 1001 Third St, Bloomington, Indiana 47405, USA.
  • Eskiocak U; Children's Research Institute and Department of Pediatrics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
  • Talpaz M; Department of Internal Medicine/Division of Hematology/Oncology, University of Michigan School of Medicine and Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA.
  • Donato NJ; Department of Pharmacology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA.
Nat Commun ; 8: 14449, 2017 02 15.
Article em En | MEDLINE | ID: mdl-28198367
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 1_ASSA2030 Problema de saúde: 1_doencas_nao_transmissiveis Assunto principal: Regulação Neoplásica da Expressão Gênica / Ubiquitina Tiolesterase / Proteína Proto-Oncogênica c-ets-1 / Ubiquitinação / Carcinogênese / GTP Fosfo-Hidrolases / Melanoma / Proteínas de Membrana Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 1_ASSA2030 Problema de saúde: 1_doencas_nao_transmissiveis Assunto principal: Regulação Neoplásica da Expressão Gênica / Ubiquitina Tiolesterase / Proteína Proto-Oncogênica c-ets-1 / Ubiquitinação / Carcinogênese / GTP Fosfo-Hidrolases / Melanoma / Proteínas de Membrana Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos