Bacterial superantigen toxins induce a lethal cytokine storm by enhancing B7-2/CD28 costimulatory receptor engagement, a critical immune checkpoint.

Kaempfer, Raymond; Popugailo, Andrey; Levy, Revital; Arad, Gila; Hillman, Dalia; Rotfogel, Ziv

Kaempfer, Raymond; Popugailo, Andrey; Levy, Revital; Arad, Gila; Hillman, Dalia; Rotfogel, Ziv.

Afiliação

Kaempfer R; Department of Biochemistry and Molecular Biology, Institute of Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 9112102 Jerusalem, Israel.
Popugailo A; Department of Biochemistry and Molecular Biology, Institute of Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 9112102 Jerusalem, Israel.
Levy R; Department of Biochemistry and Molecular Biology, Institute of Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 9112102 Jerusalem, Israel.
Arad G; Department of Biochemistry and Molecular Biology, Institute of Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 9112102 Jerusalem, Israel.
Hillman D; Department of Biochemistry and Molecular Biology, Institute of Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 9112102 Jerusalem, Israel.
Rotfogel Z; Department of Biochemistry and Molecular Biology, Institute of Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 9112102 Jerusalem, Israel.

Receptors Clin Investig ; 4(1)2017.

Article em En | MEDLINE | ID: mdl-28286804

Palavras-chave

B7-2; B7-2 dimer interface peptides; CD28; bacterial superantigens; costimulatory receptors; inflammatory cytokine storm; toxic shock

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Receptors Clin Investig Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Israel

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