Three-Component Reaction of Benzylamines, Diethyl Phosphite and Triethyl Orthoformate: Dependence of the Reaction Course on the Structural Features of the Substrates and Reaction Conditions.

Miszczyk, Patrycja; Turowska-Tyrk, Ilona; Kafarski, Pawel; Chmielewska, Ewa

Miszczyk, Patrycja; Turowska-Tyrk, Ilona; Kafarski, Pawel; Chmielewska, Ewa.

Afiliação

Miszczyk P; Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland. patrycja.miszczyk@pwr.edu.pl.
Turowska-Tyrk I; The Advanced Materials Engineering and Modelling Group, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland. ilona.turowska-tyrk@pwr.edu.pl.
Kafarski P; Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland. pawel.kafarski@pwr.edu.pl.
Chmielewska E; Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland. ewa.chmielewska@pwr.edu.pl.

Molecules ; 22(3)2017 Mar 11.

Article em En | MEDLINE | ID: mdl-28287472

ABSTRACT

ABSTRACT

The reaction between benzyl amines, triethyl orthoformate, and diethyl phosphite affords either bisphosphonic (compound 1) or N-benzylaminobenzylphosphonic (compound 2) acid depending on the reaction conditions. The final output of the reaction can be manipulated by the choice of reaction conditions, particularly the molar ratio of substrates.

Assuntos

Benzilaminas/química; Difosfonatos/síntese química; Formiatos/química; Organofosfonatos/síntese química; Fosfitos/química; Catálise; Técnicas de Química Sintética; Cristalografia por Raios X; Modelos Moleculares

Palavras-chave

N-benzylaminobenzylphosphonates; N-benzylaminomethylenebisphosphonic acid; aminophosphonates; bisphosphonates; multicomponent reactions; synthesis of C-P bond

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzilaminas / Fosfitos / Difosfonatos / Organofosfonatos / Formiatos Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Polônia

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