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Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability.
Wang, Xiaojing; Kolesnikov, Aleksandr; Tay, Suzanne; Chan, Grace; Chao, Qi; Do, Steven; Drummond, Jason; Ebens, Allen J; Liu, Ning; Ly, Justin; Harstad, Eric; Hu, Huiyong; Moffat, John; Munugalavadla, Veerendra; Murray, Jeremy; Slaga, Dionysos; Tsui, Vickie; Volgraf, Matthew; Wallweber, Heidi; Chang, Jae H.
Afiliação
  • Wang X; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Kolesnikov A; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Tay S; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Chan G; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Chao Q; ChemPartner , No. 1 Building, 998 Halei Road, Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai 201203, China.
  • Do S; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Drummond J; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Ebens AJ; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Liu N; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Ly J; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Harstad E; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Hu H; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Moffat J; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Munugalavadla V; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Murray J; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Slaga D; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Tsui V; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Volgraf M; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Wallweber H; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Chang JH; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
J Med Chem ; 60(10): 4458-4473, 2017 05 25.
Article em En | MEDLINE | ID: mdl-28445037
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteínas Quinases / Proteínas Proto-Oncogênicas c-pim-1 / Indazóis Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteínas Quinases / Proteínas Proto-Oncogênicas c-pim-1 / Indazóis Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos