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Full genetic characterization and epidemiology of a novel amdoparvovirus in striped skunk (Mephitis mephitis).
Canuti, Marta; Doyle, Hillary E; P Britton, Ann; Lang, Andrew S.
Afiliação
  • Canuti M; Department of Biology, Memorial University of Newfoundland, St John's, NL A1B3X9, Canada.
  • Doyle HE; Department of Biology, Memorial University of Newfoundland, St John's, NL A1B3X9, Canada.
  • P Britton A; Animal Health Centre, BC Ministry of Agriculture, Abbotsford, BC V3G2M3, Canada.
  • Lang AS; Department of Biology, Memorial University of Newfoundland, St John's, NL A1B3X9, Canada.
Emerg Microbes Infect ; 6(5): e30, 2017 May 10.
Article em En | MEDLINE | ID: mdl-28487558
ABSTRACT
Amdoparvovirus is a newly defined parvoviral genus that contains four species (Carnivore amdoparvovirus 1-4), including the well-known Aleutian mink disease virus (AMDV). Amdoparvoviruses cause an immune-associated and often lethal wasting syndrome in Mustelidae and Caninae hosts. In this study, we molecularly investigated amdoparvoviruses detected in 44 striped skunks (Mephitis mephitis) found dead in and around Vancouver, British Columbia, Canada. Some of the animals exhibited pathological changes compatible with amdoparvovirus-associated disease. The nearly complete genomic sequence was obtained for seven different strains and our analyses show how this virus, which we named skunk amdoparvovirus (SKAV), should be classified as a separate species within the genus (proposed Carnivore amdoparvovirus 5). We detected co-infections, recombinant genomes, at least three separate viral lineages, and preliminary evidence for geographic segregation of lineages. Furthermore, we proved that similar viruses, only partially characterized in previous studies and labeled as AMDV, circulate in skunks from other distant areas of North America (Ontario and California) and found evidence for spillover events in mink (Neovison vison). Although SKAVs are capable of causing disease in infected animals, a high proportion of sub-clinical infections has been observed, suggesting these animals might act as asymptomatic carriers and pose a threat to wild and captive carnivores. Finally, we highlight the need for more specific diagnostic tests and further molecular investigations to clarify the epidemiology and host- and geographical distributions of amdoparvoviruses in terrestrial carnivores, especially because the whole spectrum of viral diversity in this group is likely still unknown.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mephitidae / Infecções por Parvoviridae / Amdovirus / Especificidade de Hospedeiro Tipo de estudo: Screening_studies Limite: Animals País/Região como assunto: America do norte Idioma: En Revista: Emerg Microbes Infect Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Canadá

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mephitidae / Infecções por Parvoviridae / Amdovirus / Especificidade de Hospedeiro Tipo de estudo: Screening_studies Limite: Animals País/Região como assunto: America do norte Idioma: En Revista: Emerg Microbes Infect Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Canadá
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