Methamphetamine potentiates HIV-1gp120-induced microglial neurotoxic activity by enhancing microglial outward K<sup>+</sup> current.

Liu, Jianuo; Xu, Enquan; Tu, Guihua; Liu, Han; Luo, Jiangtao; Xiong, Huangui

Methamphetamine potentiates HIV-1gp120-induced microglial neurotoxic activity by enhancing microglial outward K⁺ current.

Liu, Jianuo; Xu, Enquan; Tu, Guihua; Liu, Han; Luo, Jiangtao; Xiong, Huangui.

Afiliação

Liu J; The Neurophysiology Laboratory, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5880, United States. Electronic address: jnliu@unmc.edu.
Xu E; The Neurophysiology Laboratory, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5880, United States.
Tu G; The Neurophysiology Laboratory, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5880, United States.
Liu H; The Neurophysiology Laboratory, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5880, United States.
Luo J; Department of Biostatistics, College of Public Health, University Nebraska Medical Center, Omaha, NE 68198-4375, United States.
Xiong H; The Neurophysiology Laboratory, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5880, United States. Electronic address: hxiong@unmc.edu.

Mol Cell Neurosci ; 82: 167-175, 2017 07.

Article em En | MEDLINE | ID: mdl-28552341

Assuntos

Proteína gp120 do Envelope de HIV/metabolismo; Metanfetamina/farmacologia; Microglia/metabolismo; Potássio/metabolismo; Animais; Células Cultivadas; Feminino; Neurônios/metabolismo; Ratos Sprague-Dawley; Transdução de Sinais/fisiologia; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

Drug abuse; HIV protein; Microglia; Neurodegeneration; Voltage-gated K channel

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Potássio / Proteína gp120 do Envelope de HIV / Microglia / Metanfetamina Limite: Animals Idioma: En Revista: Mol Cell Neurosci Assunto da revista: BIOLOGIA MOLECULAR / NEUROLOGIA Ano de publicação: 2017 Tipo de documento: Article

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