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Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium.
Farzan, Niloufar; Vijverberg, Susanne J; Andiappan, Anand K; Arianto, Lambang; Berce, Vojko; Blanca-López, Natalia; Bisgaard, Hans; Bønnelykke, Klaus; Burchard, Esteban G; Campo, Paloma; Canino, Glorisa; Carleton, Bruce; Celedón, Juan C; Chew, Fook Tim; Chiang, Wen Chin; Cloutier, Michelle M; Daley, Denis; Den Dekker, Herman T; Dijk, F Nicole; Duijts, Liesbeth; Flores, Carlos; Forno, Erick; Hawcutt, Daniel B; Hernandez-Pacheco, Natalia; de Jongste, Johan C; Kabesch, Michael; Koppelman, Gerard H; Manolopoulos, Vangelis G; Melén, Erik; Mukhopadhyay, Somnath; Nilsson, Sara; Palmer, Colin N; Pino-Yanes, Maria; Pirmohamed, Munir; Potocnik, Uros; Raaijmakers, Jan A; Repnik, Katja; Schieck, Maximilian; Sio, Yang Yie; Smyth, Rosalind L; Szalai, Csaba; Tantisira, Kelan G; Turner, Steve; van der Schee, Marc P; Verhamme, Katia M; Maitland-van der Zee, Anke H.
Afiliação
  • Farzan N; Division of Pharmacoepidemiology & Clinical Pharmacology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
  • Vijverberg SJ; Department of Respiratory Medicine, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands.
  • Andiappan AK; Division of Pharmacoepidemiology & Clinical Pharmacology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
  • Arianto L; Department of Respiratory Medicine, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands.
  • Berce V; Singapore Immunology Network, Agency for Science, Technology & Research, Singapore 138648, Singapore.
  • Blanca-López N; Copenhagen Prospective Studies on Asthma in Childhood, Herlev & Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
  • Bisgaard H; Department of Pediatrics, University Medical Centre Maribor, Maribor, Slovenia.
  • Bønnelykke K; Centre for Human Molecular Genetics & Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor, Slovenia.
  • Burchard EG; Allergy Service, Infanta Leonor Hospital, Madrid, Spain.
  • Campo P; Copenhagen Prospective Studies on Asthma in Childhood, Herlev & Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
  • Canino G; Copenhagen Prospective Studies on Asthma in Childhood, Herlev & Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
  • Carleton B; Departments of Medicine, Bioengineering & Therapeutic Sciences University of California, San Francisco, CA 94110, USA.
  • Celedón JC; Allergy Unit, IBIMA, Regional University Hospital of Malaga, Malaga, Spain.
  • Chew FT; Behavioral Sciences institute, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico.
  • Chiang WC; Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
  • Cloutier MM; Division of Pulmonary Medicine, Allergy, & Immunology, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA 15224, USA.
  • Daley D; Department of Biological Sciences, National University of Singapore, Singapore, & the Allergy & Immunology Division, Department of Paediatric Medicine, KK Children's Hospital, Singapore.
  • Den Dekker HT; Department of Biological Sciences, National University of Singapore, Singapore, & the Allergy & Immunology Division, Department of Paediatric Medicine, KK Children's Hospital, Singapore.
  • Dijk FN; Asthma Center, Connecticut Children's Medical Center, University of Connecticut Health Center, CT 06106, USA.
  • Duijts L; Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, Canada.
  • Flores C; Department of Pediatrics, Division of Respiratory Medicine & Allergology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Forno E; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Hawcutt DB; Department of Pediatric Pulmonology & Pediatric Allergology, University Medical Center Groningen, University of Groningen, Beatrix Children's Hospital, Groningen, The Netherlands.
  • Hernandez-Pacheco N; Groningen Research Institute for Asthma & COPD, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • de Jongste JC; Department of Pediatrics, Division of Respiratory Medicine & Allergology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Kabesch M; Department of Pediatrics, Division of Neonatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Koppelman GH; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
  • Manolopoulos VG; Research Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.
  • Melén E; Division of Pulmonary Medicine, Allergy, & Immunology, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA 15224, USA.
  • Mukhopadhyay S; Alder Hey Children's Hospital, Liverpool, UK.
  • Nilsson S; Department of Women's & Children's Health, University of Liverpool, Liverpool, UK.
  • Palmer CN; Research Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.
  • Pino-Yanes M; Department of Pediatrics, Division of Respiratory Medicine & Allergology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Pirmohamed M; Department of Pediatric Pneumology & Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany.
  • Potocnik U; Department of Pediatric Pulmonology & Pediatric Allergology, University Medical Center Groningen, University of Groningen, Beatrix Children's Hospital, Groningen, The Netherlands.
  • Raaijmakers JA; Groningen Research Institute for Asthma & COPD, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Repnik K; Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
  • Schieck M; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Sio YY; Centre of Occupational & Environmental Medicine, Stockholm County Council, Stockholm, Sweden.
  • Smyth RL; Academic Department of Paediatrics, Brighton & Sussex Medical School, Royal Alexandra Children's Hospital, Brighton, UK.
  • Szalai C; Population Pharmacogenetics Group, Biomedical Research Institute, Ninewells Hospital & Medical School University of Dundee, Dundee, UK.
  • Tantisira KG; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Turner S; Centre of Occupational & Environmental Medicine, Stockholm County Council, Stockholm, Sweden.
  • van der Schee MP; Population Pharmacogenetics Group, Biomedical Research Institute, Ninewells Hospital & Medical School University of Dundee, Dundee, UK.
  • Verhamme KM; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
  • Maitland-van der Zee AH; Research Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.
Pharmacogenomics ; 18(10): 931-943, 2017 07.
Article em En | MEDLINE | ID: mdl-28639505
ABSTRACT

AIM:

International collaboration is needed to enable large-scale pharmacogenomics studies in childhood asthma. Here, we describe the design of the Pharmacogenomics in Childhood Asthma (PiCA) consortium. MATERIALS &

METHODS:

Investigators of each study participating in PiCA provided data on the study characteristics by answering an online questionnaire.

RESULTS:

A total of 21 studies, including 14,227 children/young persons (58% male), from 12 different countries are currently enrolled in the PiCA consortium. Fifty six percent of the patients are Caucasians. In total, 7619 were inhaled corticosteroid users. Among patients from 13 studies with available data on asthma exacerbations, a third reported exacerbations despite inhaled corticosteroid use. In the future pharmacogenomics studies within the consortium, the pharmacogenomics analyses will be performed separately in each center and the results will be meta-analyzed.

CONCLUSION:

PiCA is a valuable platform to perform pharmacogenetics studies within a multiethnic pediatric asthma population.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Farmacogenética / Projetos de Pesquisa / Asma / Antiasmáticos / Variantes Farmacogenômicos Limite: Child / Female / Humans / Male Idioma: En Revista: Pharmacogenomics Assunto da revista: FARMACOLOGIA / GENETICA MEDICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Farmacogenética / Projetos de Pesquisa / Asma / Antiasmáticos / Variantes Farmacogenômicos Limite: Child / Female / Humans / Male Idioma: En Revista: Pharmacogenomics Assunto da revista: FARMACOLOGIA / GENETICA MEDICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Holanda