The effect of vitamin D on MCF-7 breast cancer cell metabolism.
Bratisl Lek Listy
; 118(2): 101-106, 2017.
Article
em En
| MEDLINE
| ID: mdl-28814091
ABSTRACT
The role of vitamin D in calcium absorption and bone health is known. The studies revealed that vitamin D modulates breast cancer cell growth and it is also associated with a reduced breast cancer risk. The primary objective of this study was to highlight the metabolic effect of Vitamin D on MCF-7 breast cancer cell line. For that purpose, we checked the apoptosis, energy, amino-acid and acylcarnitine levels in cancer cells, that the study propose, that 1α, 25(OH)2D3 could inhibit cell growth in a dose and time dependent manner. IC50 dose was calculated as 145 nM for vitamin D. We observed the apoptosis level in vitamin D groups, which were 18, 28 and 38.5 % at 24, 48 and 72 hours, respectively. During metabolic screening analysis, it was observed that glutamine, methionine and glutamic acid levels were treated more by Vitamin D groups in cell line and also, that acylcarnitine level was increased in 24 and 48 hour groups when compared to the control, but decreased in 72 hours. Further studies are needed to analyze the role of amino acids and acylcarnitines for early apoptosis and cancer metabolism (Tab. 2, Fig. 4, Ref. 24).
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Problema de saúde:
6_breast_cancer
/
6_endocrine_disorders
Assunto principal:
Vitamina D
/
Vitaminas
/
Mama
/
Neoplasias da Mama
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Ciclo Celular
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Proliferação de Células
Limite:
Female
/
Humans
Idioma:
En
Revista:
Bratisl Lek Listy
Ano de publicação:
2017
Tipo de documento:
Article