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The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.
Vu, Ly P; Pickering, Brian F; Cheng, Yuanming; Zaccara, Sara; Nguyen, Diu; Minuesa, Gerard; Chou, Timothy; Chow, Arthur; Saletore, Yogesh; MacKay, Matthew; Schulman, Jessica; Famulare, Christopher; Patel, Minal; Klimek, Virginia M; Garrett-Bakelman, Francine E; Melnick, Ari; Carroll, Martin; Mason, Christopher E; Jaffrey, Samie R; Kharas, Michael G.
Afiliação
  • Vu LP; Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Pickering BF; Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, New York, USA.
  • Cheng Y; Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Zaccara S; Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, New York, USA.
  • Nguyen D; Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Minuesa G; Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Chou T; Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Chow A; Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Saletore Y; Department of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, New York, USA.
  • MacKay M; Department of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, New York, USA.
  • Schulman J; Hematologic Oncology Tissue Bank, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Famulare C; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Patel M; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Klimek VM; Memorial Sloan Kettering Cancer Center, Department of Medicine, Leukemia Service, New York, New York, USA.
  • Garrett-Bakelman FE; Department of Medicine and Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA.
  • Melnick A; Division of Hematology and Medical Oncology, Department of Medicine and Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, New York, USA.
  • Carroll M; Division of Hematology and Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Mason CE; Department of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, New York, USA.
  • Jaffrey SR; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, New York, USA.
  • Kharas MG; The Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York, USA.
Nat Med ; 23(11): 1369-1376, 2017 Nov.
Article em En | MEDLINE | ID: mdl-28920958
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 1_ASSA2030 / 2_ODS3 Problema de saúde: 1_doencas_nao_transmissiveis / 2_muertes_prematuras_enfermedades_notrasmisibles Assunto principal: Células da Medula Óssea / Leucemia Mieloide Aguda / Diferenciação Celular / Adenosina / Metiltransferases Limite: Humans Idioma: En Revista: Nat Med Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 1_ASSA2030 / 2_ODS3 Problema de saúde: 1_doencas_nao_transmissiveis / 2_muertes_prematuras_enfermedades_notrasmisibles Assunto principal: Células da Medula Óssea / Leucemia Mieloide Aguda / Diferenciação Celular / Adenosina / Metiltransferases Limite: Humans Idioma: En Revista: Nat Med Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos