Mold metabolites drive rheumatoid arthritis in mice via promotion of IFN-gamma- and IL-17-producing T cells.

Jahreis, Susanne; Kuhn, Stephanie; Madaj, Anna-Maria; Bauer, Mario; Polte, Tobias

Jahreis, Susanne; Kuhn, Stephanie; Madaj, Anna-Maria; Bauer, Mario; Polte, Tobias.

Afiliação

Jahreis S; UFZ - Helmholtz Centre for Environmental Research Leipzig-Halle, Department of Environmental Immunology, Leipzig, Germany; Department of Dermatology, Venerology and Allergology, Leipzig University Medical Center, Leipzig, Germany; Infections in Hematology/Oncology, Leibniz Institute for Natural Prod
Kuhn S; UFZ - Helmholtz Centre for Environmental Research Leipzig-Halle, Department of Environmental Immunology, Leipzig, Germany; Department of Dermatology, Venerology and Allergology, Leipzig University Medical Center, Leipzig, Germany.
Madaj AM; UFZ - Helmholtz Centre for Environmental Research Leipzig-Halle, Department of Environmental Immunology, Leipzig, Germany.
Bauer M; UFZ - Helmholtz Centre for Environmental Research Leipzig-Halle, Department of Environmental Immunology, Leipzig, Germany.
Polte T; UFZ - Helmholtz Centre for Environmental Research Leipzig-Halle, Department of Environmental Immunology, Leipzig, Germany; Department of Dermatology, Venerology and Allergology, Leipzig University Medical Center, Leipzig, Germany. Electronic address: tobias.polte@ufz.de.

Food Chem Toxicol ; 109(Pt 1): 405-413, 2017 Nov.

Article em En | MEDLINE | ID: mdl-28935500

Assuntos

Artrite Reumatoide/etiologia; Artrite Reumatoide/imunologia; Fungos/metabolismo; Interferon gama/imunologia; Interleucina-17/imunologia; Ocratoxinas/toxicidade; Tricotecenos/toxicidade; Animais; Artrite Reumatoide/genética; Feminino; Humanos; Interferon gama/genética; Interleucina-17/genética; Camundongos; Camundongos Endogâmicos DBA; Ocratoxinas/metabolismo; Células RAW 264.7; Células Th1/efeitos dos fármacos; Células Th1/imunologia; Células Th17/efeitos dos fármacos; Células Th17/imunologia; Tricotecenos/metabolismo

Palavras-chave

Mycotoxin; Rheumatoid arthritis; Stat signalling; T cell differentiation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Tricotecenos / Interferon gama / Interleucina-17 / Fungos / Ocratoxinas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans Idioma: En Revista: Food Chem Toxicol Ano de publicação: 2017 Tipo de documento: Article

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