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Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors.
Henssen, Anton G; Reed, Casie; Jiang, Eileen; Garcia, Heathcliff Dorado; von Stebut, Jennifer; MacArthur, Ian C; Hundsdoerfer, Patrick; Kim, Jun Hyun; de Stanchina, Elisa; Kuwahara, Yasumichi; Hosoi, Hajime; Ganem, Neil J; Dela Cruz, Filemon; Kung, Andrew L; Schulte, Johannes H; Petrini, John H; Kentsis, Alex.
Afiliação
  • Henssen AG; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Reed C; Berlin Institute of Health, 10178 Berlin, Germany.
  • Jiang E; Department of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
  • Garcia HD; German Cancer Consortium (DKTK), 10117 Berlin, Germany.
  • von Stebut J; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • MacArthur IC; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Hundsdoerfer P; Department of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
  • Kim JH; Department of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
  • de Stanchina E; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Kuwahara Y; Berlin Institute of Health, 10178 Berlin, Germany.
  • Hosoi H; Department of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
  • Ganem NJ; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Dela Cruz F; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Kung AL; Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  • Schulte JH; Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  • Petrini JH; Section of Hematology and Medical Oncology, Department of Pharmacology, Boston University School of Medicine, Boston, MA 02215, USA.
  • Kentsis A; Department of Pediatrics, Weill Cornell Medical College of Cornell University and Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Sci Transl Med ; 9(414)2017 Nov 01.
Article em En | MEDLINE | ID: mdl-29093183
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 2_ODS3 / 7_ODS3_muertes_prevenibles_nacidos_ninos Problema de saúde: 2_muertes_prevenibles / 7_non_communicable_diseases Assunto principal: Pirimidinas / Sulfóxidos / Transposases / Reparo do DNA / Terapia de Alvo Molecular / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Child / Humans Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 2_ODS3 / 7_ODS3_muertes_prevenibles_nacidos_ninos Problema de saúde: 2_muertes_prevenibles / 7_non_communicable_diseases Assunto principal: Pirimidinas / Sulfóxidos / Transposases / Reparo do DNA / Terapia de Alvo Molecular / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Child / Humans Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos