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A transfer-RNA-derived small RNA regulates ribosome biogenesis.
Kim, Hak Kyun; Fuchs, Gabriele; Wang, Shengchun; Wei, Wei; Zhang, Yue; Park, Hyesuk; Roy-Chaudhuri, Biswajoy; Li, Pan; Xu, Jianpeng; Chu, Kirk; Zhang, Feijie; Chua, Mei-Sze; So, Samuel; Zhang, Qiangfeng Cliff; Sarnow, Peter; Kay, Mark A.
Afiliação
  • Kim HK; Department of Pediatrics, Stanford University, Stanford, California 94305, USA.
  • Fuchs G; Department of Genetics, Stanford University, Stanford, California 94305, USA.
  • Wang S; Department of Microbiology and Immunology, Stanford University, Stanford, California 94305, USA.
  • Wei W; Department of Pediatrics, Stanford University, Stanford, California 94305, USA.
  • Zhang Y; Department of Genetics, Stanford University, Stanford, California 94305, USA.
  • Park H; Asian Liver Center, Department of Surgery, Stanford University School of Medicine, Stanford, California 94305, USA.
  • Roy-Chaudhuri B; Department of Pediatrics, Stanford University, Stanford, California 94305, USA.
  • Li P; Department of Genetics, Stanford University, Stanford, California 94305, USA.
  • Xu J; Department of Pediatrics, Stanford University, Stanford, California 94305, USA.
  • Chu K; Department of Genetics, Stanford University, Stanford, California 94305, USA.
  • Zhang F; Department of Pediatrics, Stanford University, Stanford, California 94305, USA.
  • Chua MS; Department of Genetics, Stanford University, Stanford, California 94305, USA.
  • So S; MOE Key Laboratory of Bioinformatics, Beijing Advanced Innovation Center for Structural Biology, Center for Synthetic and Systems Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
  • Zhang QC; Department of Pediatrics, Stanford University, Stanford, California 94305, USA.
  • Sarnow P; Department of Genetics, Stanford University, Stanford, California 94305, USA.
  • Kay MA; Department of Pediatrics, Stanford University, Stanford, California 94305, USA.
Nature ; 552(7683): 57-62, 2017 12 07.
Article em En | MEDLINE | ID: mdl-29186115
ABSTRACT
Transfer-RNA-derived small RNAs (tsRNAs; also called tRNA-derived fragments) are an abundant class of small non-coding RNAs whose biological roles are not well understood. Here we show that inhibition of a specific tsRNA, LeuCAG3'tsRNA, induces apoptosis in rapidly dividing cells in vitro and in a patient-derived orthotopic hepatocellular carcinoma model in mice. This tsRNA binds at least two ribosomal protein mRNAs (RPS28 and RPS15) to enhance their translation. A decrease in translation of RPS28 mRNA blocks pre-18S ribosomal RNA processing, resulting in a reduction in the number of 40S ribosomal subunits. These data establish a post-transcriptional mechanism that can fine-tune gene expression during different physiological states and provide a potential new target for treating cancer.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Problema de saúde: 6_digestive_diseases / 6_liver_cancer Assunto principal: Proteínas Ribossômicas / Ribossomos / RNA de Transferência de Leucina / Pequeno RNA não Traduzido Idioma: En Revista: Nature Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Problema de saúde: 6_digestive_diseases / 6_liver_cancer Assunto principal: Proteínas Ribossômicas / Ribossomos / RNA de Transferência de Leucina / Pequeno RNA não Traduzido Idioma: En Revista: Nature Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos