Plakoglobin localization to the cell border restores desmosome function in cells lacking 14-3-3γ.
Biochem Biophys Res Commun
; 495(2): 1998-2003, 2018 01 08.
Article
em En
| MEDLINE
| ID: mdl-29253567
ABSTRACT
Desmosomes are cell-cell adhesion junctions that anchor intermediate filaments. Loss of 14-3-3γ in HCT116â¯cells led to defects in desmosome assembly due to a decrease in the transport of Plakoglobin (PG) to the cell border thus disrupting desmosome formation. Desmosome formation in cells lacking 14-3-3γ was restored by artificially localizing PG to the cell border by fusing it to EGFP-f (PG-EGFP-f). These results suggest that a major role of 14-3-3γ in desmosome assembly is to transport PG to the cell border leading to the initiation of desmosome formation.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Frações Subcelulares
/
Neoplasias Colorretais
/
Membrana Celular
/
Proteínas 14-3-3
/
Desmossomos
Limite:
Humans
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Índia