ExoY, an actin-activated nucleotidyl cyclase toxin from P. aeruginosa: A minireview.
Toxicon
; 149: 65-71, 2018 Jul.
Article
em En
| MEDLINE
| ID: mdl-29258848
ABSTRACT
ExoY is one of four well-characterized Pseudomonas aeruginosa type 3 secretion system (T3SS) effectors. It is a nucleotidyl cyclase toxin that is inactive inside the bacteria, but becomes potently activated once it is delivered into the eukaryotic target cells. Recently, filamentous actin was identified as the eukaryotic cofactor that stimulates specifically ExoY enzymatic activity by several orders of magnitude. In this review, we discuss recent advances in understanding the biochemistry of nucleotidyl cyclase activity of ExoY and its regulation by interaction with filamentous actin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pseudomonas aeruginosa
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Proteínas de Bactérias
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Citoesqueleto de Actina
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Glucosiltransferases
Idioma:
En
Revista:
Toxicon
Ano de publicação:
2018
Tipo de documento:
Article