Immunohistochemical study on the distribution of ß-defensin 1 and ß-defensin 2 throughout the respiratory tract of healthy rats.
J Vet Med Sci
; 80(3): 395-404, 2018 Mar 24.
Article
em En
| MEDLINE
| ID: mdl-29311494
ABSTRACT
The distributions of ß-defensin 1 and 2 in secretory host defense system throughout respiratory tract of healthy rats were immunohistochemically investigated. In the nasal epithelium, a large number of non-ciliated and non-microvillous cells (NCs) were immunopositive for both ß-defensin 1 and 2, whereas a small number of goblet cells (GCs) were immunopositive only for ß-defensin 1. Beta-defensin 2-immunopositive GCs were few. In the nasal glands, a small number of acinar cells and a large number of ductal epithelial cells were immunopositive for both ß-defensins. In the laryngeal and tracheal epithelia, a very few NCs and GCs were immunopositive for both ß-defensins. In laryngeal and tracheal glands, a very few acinar cells and a large number of ductal epithelial cells were immunopositive for both ß-defensins. In the extra-pulmonary bronchus, a small number of NCs were immunopositive for both ß-defensins. A small number of GCs were immunopositive for ß-defensin 1, whereas few GCs were immunopositive for ß-defensin 2. From the intra-pulmonary bronchus to alveoli, a very few or no epithelial cells were immunopositive for both ß-defensins. In the mucus and periciliary layers, ß-defensin 1 was detected from the nose to the extra-pulmonary bronchus, whereas ß-defensin 2 was weakly detected only in the nose and the larynx. These findings suggest that the secretory sources of ß-defensin 1 and 2 are mainly distributed in the nasal mucosa and gradually decrease toward the caudal airway in healthy rats.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistema Respiratório
/
Defensinas
/
Beta-Defensinas
Limite:
Animals
Idioma:
En
Revista:
J Vet Med Sci
Assunto da revista:
MEDICINA VETERINARIA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Japão