Karyoptosis: A novel type of cell death caused by chronic autophagy inhibition.
Autophagy
; 14(4): 722-723, 2018.
Article
em En
| MEDLINE
| ID: mdl-29388501
ABSTRACT
Macroautophagy/autophagy influences onset and progression of several human neurodegenerative diseases, because of its critical role as a regulator of neuronal proteostasis and organelle quality control. In many neurodegenerative diseases, impairment in autophagy is thought to play a fundamental part in the terminal phases of cellular degeneration and death. However, the ultimate mechanism of neuronal cell death remains elusive. In a recent study we have identified a new form of regulated cell death, which arises upon autophagy inhibition.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autofagia
/
Morte Celular
/
Doenças Neurodegenerativas
/
Neurônios
Limite:
Humans
Idioma:
En
Revista:
Autophagy
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Reino Unido