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Adaptive antibody diversification through N-linked glycosylation of the immunoglobulin variable region.
van de Bovenkamp, Fleur S; Derksen, Ninotska I L; Ooijevaar-de Heer, Pleuni; van Schie, Karin A; Kruithof, Simone; Berkowska, Magdalena A; van der Schoot, C Ellen; IJspeert, Hanna; van der Burg, Mirjam; Gils, Ann; Hafkenscheid, Lise; Toes, René E M; Rombouts, Yoann; Plomp, Rosina; Wuhrer, Manfred; van Ham, S Marieke; Vidarsson, Gestur; Rispens, Theo.
Afiliação
  • van de Bovenkamp FS; Sanquin Research, Department of Immunopathology, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, 1066 CX, Amsterdam, The Netherlands; s.vandebovenkamp@sanquin.nl.
  • Derksen NIL; Sanquin Research, Department of Immunopathology, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, 1066 CX, Amsterdam, The Netherlands.
  • Ooijevaar-de Heer P; Sanquin Research, Department of Immunopathology, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, 1066 CX, Amsterdam, The Netherlands.
  • van Schie KA; Sanquin Research, Department of Immunopathology, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, 1066 CX, Amsterdam, The Netherlands.
  • Kruithof S; Sanquin Research, Department of Immunopathology, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, 1066 CX, Amsterdam, The Netherlands.
  • Berkowska MA; Sanquin Research, Department of Experimental Immunohematology, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, 1066 CX, Amsterdam, The Netherlands.
  • van der Schoot CE; Sanquin Research, Department of Experimental Immunohematology, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, 1066 CX, Amsterdam, The Netherlands.
  • IJspeert H; Erasmus Medical Center, Department of Immunology, University Medical Center Rotterdam, 3015 CE, Rotterdam, The Netherlands.
  • van der Burg M; Erasmus Medical Center, Department of Immunology, University Medical Center Rotterdam, 3015 CE, Rotterdam, The Netherlands.
  • Gils A; Laboratory for Therapeutic and Diagnostic Antibodies, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, 3000 Belgium.
  • Hafkenscheid L; Department of Rheumatology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.
  • Toes REM; Department of Rheumatology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.
  • Rombouts Y; Department of Rheumatology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.
  • Plomp R; Center for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.
  • Wuhrer M; Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, Université Paul Sabatier, 31400 Toulouse, France.
  • van Ham SM; Center for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.
  • Vidarsson G; Center for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.
  • Rispens T; Sanquin Research, Department of Immunopathology, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, 1066 CX, Amsterdam, The Netherlands.
Proc Natl Acad Sci U S A ; 115(8): 1901-1906, 2018 02 20.
Article em En | MEDLINE | ID: mdl-29432186
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Região Variável de Imunoglobulina Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Região Variável de Imunoglobulina Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2018 Tipo de documento: Article