Stochastic Pharmacokinetic-Pharmacodynamic Modeling for Assessing the Systemic Health Risk of Perfluorooctanoate (PFOA).

Convertino, Matteo; Church, Timothy R; Olsen, Geary W; Liu, Yang; Doyle, Eddie; Elcombe, Clifford R; Barnett, Anna L; Samuel, Leslie M; MacPherson, Iain R; Evans, Thomas R J

Convertino, Matteo; Church, Timothy R; Olsen, Geary W; Liu, Yang; Doyle, Eddie; Elcombe, Clifford R; Barnett, Anna L; Samuel, Leslie M; MacPherson, Iain R; Evans, Thomas R J.

Afiliação

Convertino M; Division of Environmental Health Sciences and Public Health Informatics Program, HumNat Lab, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55455.
Church TR; Institute on the Environment, University of Minnesota, St. Paul, Minnesota 55455.
Olsen GW; Institute for Engineering in Medicine.
Liu Y; Biomedical Informatics and Computational Biology Program.
Doyle E; Division of Environmental Health Sciences, School of Public Health.
Elcombe CR; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455.
Barnett AL; Medical Department, 3M Company, St. Paul, Minnesota 55144.
Samuel LM; Division of Environmental Health Sciences and Public Health Informatics Program, HumNat Lab, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55455.
MacPherson IR; CXR Biosciences, Dundee DD1 5JJ, UK.
Evans TRJ; CXR Biosciences, Dundee DD1 5JJ, UK.

Toxicol Sci ; 163(1): 293-306, 2018 05 01.

Article em En | MEDLINE | ID: mdl-29462473

Assuntos

Antineoplásicos; Caprilatos; Fluorocarbonos; Modelos Biológicos; Neoplasias/tratamento farmacológico; Antineoplásicos/farmacocinética; Antineoplásicos/farmacologia; Antineoplásicos/toxicidade; Caprilatos/farmacocinética; Caprilatos/farmacologia; Caprilatos/toxicidade; Colesterol/sangue; Relação Dose-Resposta a Droga; Feminino; Fluorocarbonos/farmacocinética; Fluorocarbonos/farmacologia; Fluorocarbonos/toxicidade; Humanos; Fígado/efeitos dos fármacos; Fígado/enzimologia; Testes de Função Hepática; Masculino; Pessoa de Meia-Idade; Neoplasias/sangue; Glândula Tireoide/efeitos dos fármacos; Tiroxina/sangue; Resultado do Tratamento

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Caprilatos / Fluorocarbonos / Modelos Biológicos / Neoplasias / Antineoplásicos Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Toxicol Sci Assunto da revista: TOXICOLOGIA Ano de publicação: 2018 Tipo de documento: Article

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