Three patients with advanced cutaneous angiosarcoma treated with eribulin: investigation of serum soluble CD163 and chemokine (C-X-C motif) ligand 10 as possible biomarkers predicting the biological behaviour of angiosarcoma.
Br J Dermatol
; 179(6): 1392-1395, 2018 12.
Article
em En
| MEDLINE
| ID: mdl-29663331
ABSTRACT
Cutaneous angiosarcoma (CAS) is a highly aggressive vascular tumour that recurs locally and metastasizes early. Although chemoradiotherapy with taxanes shows a high response rate with prolonged survival, second-line therapy for advanced CAS remains contentious. This report describes three patients with advanced CAS treated with eribulin. In addition, we investigated serum soluble (s)CD163, chemokine (C-X-C motif) ligand 10 (CXCL10) and chemokine (C-C motif) ligand 2 levels at several time points of tumour progression in these patients, revealing serum levels of sCD163 and CXCL10 as potential biomarkers for progression of CAS.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
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Antígenos de Diferenciação Mielomonocítica
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Biomarcadores Tumorais
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Antígenos CD
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Receptores de Superfície Celular
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Quimiocina CXCL10
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Furanos
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Cetonas
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Hemangiossarcoma
Tipo de estudo:
Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Br J Dermatol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Japão